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News

New MenB Vaccine Shows Promise in Early-Stage Trial Results

The outcome of a trial published in Science Translational Medicine, shows encouraging results for a new vaccine targeting group B meningococcus (MenB), a significant cause of meningococcal disease worldwide, and establishes proof-of-concept in humans that a gene-based vaccine platform can induce protective antibody responses against bacteria.

Study identifies key immune structures in the gut that may drive coeliac disease

Researchers in Oxford have found structures of immune cells in the gut that may be driving the response to gluten in people with coeliac disease and could provide a target for future therapies.

Study shows urgent change needed to reduce deaths from malaria and meningitis in comatose African children

Results of two parallel studies show that one in four African children hospitalised with malaria and coma have an additional infection, and that giving antibiotics with antimalarials could help reduce death rates of comatose children.

Spotlight on Magdalen College Chapel for Rare Disease Day

The chapel facade of Magdalen College was lit up ahead of the commemoration of Rare Disease Day (RDD) which was celebrated on Friday 28th February 2025. The celebration is held on 29th February in a leap year as it is the rarest day in the year.

New partnership to advance public health and life science research collaboration in West Africa

The Pandemic Sciences Institute, including principal investigators from the Oxford Vaccine Group, has signed a memorandum of understanding with Institut Pasteur de Dakar (IPD) to become a partner institution. PSI and Institut Pasteur de Dakar (IPD) will cooperate on developing vaccines and rapid diagnostics – as well as strengthening workforce in the vaccinology, clinical trials and biomanufacturing sectors.

New study shows that early support for children living in marginalised communities can improve their developmental outcomes

Research by experts at the Department of Paediatrics, and published in the European Journal of Paediatrics shows that early interventions of support to the development of children living in disadvantaged settings, can significantly improve their neurodevelopmental outcomes during early childhood.

Oxford and partners lead on two new MRC Centres to create cutting-edge gene therapies

Oxford University researchers are to lead and co-lead on two MRC research centres, which are being launched to develop new advanced treatments for currently untreatable diseases.

Trial results for first vaccine against blood-stage malaria show it is well-tolerated and offers effective protection

Results of a clinical trial into a new malaria vaccine candidate (RH5.1/Matrix-M) show it is well-tolerated and offers effective protection against the blood-stage of the disease – the first inoculation to do so.

Dr. Nicky Whiffin awarded Balfour Lecture 2025

Nicky Whiffin, Associate Professor and Sir Henry Dale Fellow at the University of Oxford’s Big Data Institute and Centre for Human Genetics, has been awarded the 2025 Balfour Lecture by the Genetics Society.

University of Oxford unveils new vaccine development partnership

Oxford Cancer, the Oxford Vaccine Group and the Pandemic Sciences Institute have announced a new collaboration with Belgian Biotech Innovator, Univercells.

Ineos Oxford Institute makes award to OVG project tackling antimicrobial resistance

The Ineos Oxford Institute for antimicrobial research (IOI) has awarded over £2m to six projects across the University of Oxford focused on developing new solutions to tackle antimicrobial resistance (AMR), including one at the Oxford Vaccine Group.

David Cameron resumes role as chair of Advisory Council for Oxford-Harrington Rare Disease Centre (OHC)

Former UK Prime Minister David Cameron has resumed his role as chair of the OHC Advisory Council, a position he originally undertook in October 2023 prior to his appointment as Foreign Secretary.

Typhoid vaccine trial confirms sustained protection for older children

A single dose of typhoid conjugate vaccine (TCV) offers safe, effective protection against typhoid two years after vaccination in all children, and sustained protection for older children at three to five years post immunisation, according to a report by researchers at the Oxford Vaccine Group and icddr,b. But it also shows a decline in protection at the later timepoints among children vaccinated at younger ages.

New campaign launched to encourage vaccine uptake

Oxford Vaccine Group marks 30 years battling ‘deadly six’ diseases with major art installation

A major art installation featuring dramatically upscaled bacteria, viruses and a parasite has been unveiled at Oxford University’s Museum of Natural History to celebrate 30 years of vaccine development by the Oxford Vaccine Group (OVG) which has tackled some of the world’s most deadly diseases.

Launch of new podcast series Trusting the Science

The Oxford Vaccine Group is celebrating 30 years of life-saving vaccine development with the release of a new podcast series of conversations called Trusting the Science. This is the second series of The Oxford Colloquy - discourses hosted by Professor Sir Andrew Pollard who has been Director of the group for over 20 years - and each episode delves into the crucial role that science plays in our understanding of health and immunity.

Athena Swan Gold award

The Department of Paediatrics has been awarded the Athena Swan Gold award for its commitment to advancing gender equality in higher education. Established in 2005 to encourage and recognise commitment to advancing the careers of women in science, technology, engineering, maths and medicine (STEMM) employment, the Charter is now used across the globe to address gender equality and barriers to progression that affect women.

New research identifies autoimmunity against a key anti-inflammatory regulator in inflammatory bowel disease

A ground-breaking study, published by the New England Journal of Medicine, has identified a new disease-inducing mechanism for inflammatory bowel disease (IBD) in which the immune system attacks its own regulatory function.

Oxford scientists launch first-in-human vaccine trial for deadly Marburg virus

Scientists at the University of Oxford have launched a new clinical trial to test a vaccine to protect people against deadly Marburg virus.

New discovery renews hope for thousands with neurodevelopment disorders

A global collaboration led by scientists at the University of Oxford has discovered that genetic variants in a specific gene cause a rare neurodevelopmental disorder (NDD). NDD is a collective term for severe impairments in how the brain functions that impact learning, behaviour, speech, and movement. Most NDDs are thought to be genetic and caused by changes to DNA, however, to date, around 60% of individuals with these conditions do not know the specific DNA change that causes their disorder.

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