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The gastrointestinal immune system has evolved to avoid and counteract the invasion of pathogens. To allow a strong inflammatory immune response during infection but avoid tissue damage there is a need for barrier function and effective immune regulation. Defects in immune regulation lead to immunopathology such as inflammatory bowel disease or celiac disease. We study mechanisms of intestinal barrier function as well as immune regulation by analysing patients with Mendelian disorders that develop intestinal inflammation.

Mucosal histology

About one fifth of all patients with IBD present with initial symptoms during childhood and adolescents. In particular in the very young children patients an underlying immunodeficiency may cause IBD-like symptoms. The analysis of immune deviation in children with IBD and IBD-like symptoms may contribute to the understanding of the complex puzzle of molecular mechanisms involved in IBD.

Recent updates on the studies and opportunities within the Mucosal Immunology Group.

Our team

  • Holm Uhlig
    Holm Uhlig

    Professor of Paediatric Gastroenterology, Group Head / PI and Hon Consultant Physician

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