Established in 1994
Over 11,000 adults and children enrolled into clinical trials in the Thames Valley since 2001
The Oxford Vaccine Group (OVG) conducts studies of new and improved vaccines for adults and children against diseases including meningococcus, pneumococcus, RSV, influenza, typhoid and paratyphoid. The group is based in the Department of Paediatrics in the University of Oxford at the Oxford Vaccine Centre, Churchill Hospital, and is led by Professor Andrew J. Pollard.
Vaccines are a key component of global public health policy and are particularly important in the defence of the health of young children. Despite the challenges of so doing, new and improved vaccines must be evaluated in the target population of infants and young children prior to licensure. The Oxford Vaccine Group has enrolled over 10,000 children and young people into clinical trials in the Thames Valley since 2001. The clinical trials undertaken in the UK since 2001 include phase IV studies of a meningitis C vaccine and a pneumococcal conjugate vaccine; a phase II study of a new pneumococcal vaccine for infants; phase II and III studies of quadrivalent meningococcal vaccines and group B meningococcal vaccines; phase II studies of a preschool vaccine; evaluation of a novel avian and swine influenza vaccines in adults and children; study of different schedules for immunisation of the elderly against pneumococcal infection. Epidemiological studies have included evaluation of carriage of Haemophilus influenzae type b and Streptococcus pneumonia throughout childhood in the UK and Nepal, surveillance of invasive bacterial infections in children admitted to Patan hospital in Kathmandu. Qualitative research studies have evaluated parental views about immunization, vaccine research and influenza vaccines. The group has a particular interest in the ethics of consent in childhood and is working with the Centre for Ethics on studies evaluating the process of consent in school age children.
The laboratory research programme has used the clinical material provided by the clinical trials group to drive a series of projects evaluating the developing immune system in the infant. The group has specifically focused on the development of B cell memory after immunization with glycoconjugate vaccines and has found correlations between the generation of memory during priming and the persistence of the immune response. A major programme is focussed on the development of a novel serogroup B meningococcal vaccine from preclinical studies through to clinical trials. In a ground-breaking study, the group are developing a human typhoid model for the evaluation of typhoid vaccines. The group also undertakes sero-epidemiological studies and is examining acquisition of natural immunity to various organisms in the UK and Nepal. A bank of DNA is being collected form children enrolled in vaccine trials and several studies of the genetic control of the immune response following immunisation are currently underway.
History of the Oxford Vaccine Group
Our team
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Andrew Pollard
Professor of Paediatric Infection and Immunity
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Amber Thompson
Senior Research Assistant/QA Assistant
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Ann Waterhouse
Events and Technical Research Assistant
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Annabel Coxon
Clinical Trials Assistant
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Catherine Owen
PA to Professor Pollard
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Christina Dold
Post Doctoral Researcher
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Christine S. Rollier
Research Scientist – Team Head
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Claire Jones
Senior Post Doctoral Researcher
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Daniel O'Connor
Postdoctoral Researcher
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Danielle Campbell
Senior Research Nurse & Immunisation Advisor
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Dominic Kelly
BRC Consultant in Paediatrics and Vaccinology.
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Elizabeth Clutterbuck
Senior Post Doctoral Researcher
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Emma Plested
Project Manager
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Hannah Robinson
Senior Research Nurse / Clinical Co-ordinator
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Jade Fellows
Clinical Trials Support Officer
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Johannes Trück
Clinical Lecturer
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Karen Ford
Practice Educator
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Sarah Kelly
GAVI PneumoNIA Study Co-ordinator
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Laura Silva -Reyes
Research Assistant
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Laura Walker
Senior Clinical Trials Assistant
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Lucky Khan
Clinical Trials Support Officer & Harassment officer
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Louise Willis
Senior Paediatric Research Nurse
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Matthew Snape
BRC Consultant in Paediatrics and Vaccinology
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Melanie Carr
Clinical Trials Assistant
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Mildred Iro
Paediatric Research Fellow
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Priscilla McRitason
Adult Research Nurse
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Rebecca Beckley
Project Manager
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Sonu Shrestha
Research Assistant
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Sue Brockes-Smith
Conference Organiser
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Yama G.Farooq
Clinical Trials IT Manager
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Zoe Young
Research Nurse
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Celina Jin
DPhil Student
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Helena Thomaides-Brears
Post Doctoral Research Assistant
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Jessica Knedler
Clinical Trials Play and Study Assistant
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Malick Gibani
Clinical Research Fellow/DPhil candidate
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Simon Drysdale
Academic Clinical Lecturer
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Simon Kerridge
Quality Assurance Manager
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Carl Britto
DPhil Student
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Parvinder Aley
Operational Manager
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Sagida Bibi
Research Assistant
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Luke Blackwell
Research Assistant
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Jaclyn Bowman
Laboratory Assistant
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Susana Camara
Research Assistant
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Tamar Cameron
Paediatric Clinical Research Manager
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Jennifer Hill
Postdoctoral Research Assistant
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Elizabeth Jones
Research Assistant
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David Kerr
Data Entry Assistant
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James Meiring
DPhil Student
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Richard Moxon
Emeritus Professor of Paediatrics
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Jo Partington
Research Nurse
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Anna Szigeti
Clinical Trials Support Officer
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Susan Tonks
Typhoid Strategic Award Programme Manager
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Marta Valente Pinto
DPhil Student
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Samantha Vanderslott
Social sciences researcher
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Rachel White
Research Nurse
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James Gilchrist
Wellcome Trust Clinical Research Fellow
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Jonathan Gardner
Research Nurse
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Rachel Colin-Jones
Research Nurse
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Ruth Drury
DPhil Student
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Jack Attewell
Research Assistant
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Charlotte Boyer
Project Manager
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Edward Choi
Project Manager
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Emma Callen
Clinical Trials Play and Study Assistant
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Rachel Craik
Project Manager
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Jade Di'Anno
Clinical Trials Play and Study Assistant
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Xinxue Liu
Senior Statistician
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Sarah Loving
Vaccine Knowledge Project Manager
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Irina Mohorianu
Bioinformatics Lead
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Soumya Perinparajah
Research Assistant
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Camilla Tomala
Clinical Trials Receptionist/Admin Support
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Gu-Lung Lin
DPhil Student
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Rachel Anslow
Research Assistant
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Kimberly Davis
Paediatric Clinical Research Fellow
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Emily Marshall
Research Nurse
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Alex Maytum
Research Assistant
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Maria Moore
Research Nurse
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Amber Barton
DPhil Student
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Joseph McGinley
DPhil Student
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Dylan Sheerin
DPhil Student
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Alexa Dierig
Academic Visitor
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Hannah Roberts
Paediatric Research Nurse
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Sofia Scherrer
Paediatric Clinical Research Fellow
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Deborah Cross
DPhil Student
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Olga Mazur
Data Manager
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Gemma Sinclair
Research Fellow
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Naomi Douglas
Senior Research Nurse
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Katie O'Brien
Paediatric Research Nurse
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Catherine Smith
Adult Clinical Research Fellow
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Nicola Smith
Paediatric Registrar
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Rinn Song
Clinical Scientist
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Sophie Temple
Research Programme Assistant
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Stephane Paulus
Consultant in Paediatric Infectious Diseases
Nepal Earthquakes - Experiences from our colleagues
Shrijana Shrestha, Imran Ansari, Bibek Khadka & Sanjeev Bijukchhe talk about their experience of the Nepal earthquakes here. Sarah Kelly (5th from the left) has added images to the soundtrack and originally presented it at the OVG away day, but their moving stories deserve a wider audience!
Funding Sources
Wellcome Trust, European Commission, Action Medical Research, Meningitis UK, Meningitis Research Foundation, Sparks, World Health Organisation, NIHR Health Technology Assessment Programme, NIHR Oxford Biomedical Research Centre, James Martin Institute.
Recruiting Studies
If you are interested in taking part in any of the current studies, please have a look at the following recruiting studies:
http://trials.ovg.ox.ac.uk or contact: info@ovg.ox.ac.uk
Associate Members
Dr Sarah Atkinson - Senior Lecturer, Department of Paediatrics.
Dr. James Berkley - Clinical Research Fellow, Nuffield Department of Tropical Medicine
Dr. Charlotte Barker - Clinical Research Fellow, St. George's Hospital, London
Stephen Gerry - Statistician, Centre for Statistics in Medicine
Dr. Stéphane Paulus - Consultant in Infectious Diseases & Immunology, Oxford University Hospitals NHS Trust
Dr. Shelley Segal - Consultant Paediatrician, Oxford University Hospitals NHS Trust
Merryn Vosey - Clinical Trials Statistician, Department of Primary Healthcare Sciences
Dr. Mary Warrell - Honorary Senior Researcher, Oxford Vaccine Group
Vaccine Knowledge Project
This new project, funded by the NIHR Oxford Biomedical Research Centre and the Oxford Martin School, aims to make independent and authoritative scientific information available to all. It gives everyone, from teenagers to parents, access to the expertise and knowledge of Oxford Vaccine Group researchers.
This new project, funded by the NIHR Oxford Biomedical Research Centre and the Oxford Martin School, aims to make independent and authoritative scientific information available to all. It gives everyone, from teenagers to parents, access to the expertise and knowledge of Oxford Vaccine Group researchers.