Search results (26)
« Back to NewsTyphoid vaccine trial confirms sustained protection for older children
10 October 2024
Clinical Trials Informing Policy Publication Research Vaccinology
A single dose of typhoid conjugate vaccine (TCV) offers safe, effective protection against typhoid two years after vaccination in all children, and sustained protection for older children at three to five years post immunisation, according to a report by researchers at the Oxford Vaccine Group and icddr,b. But it also shows a decline in protection at the later timepoints among children vaccinated at younger ages.
New research identifies autoimmunity against a key anti-inflammatory regulator in inflammatory bowel disease
4 August 2024
Clinical Trials Department Gastroenterology Immunology Publication Research Research Methods University
A ground-breaking study, published by the New England Journal of Medicine, has identified a new disease-inducing mechanism for inflammatory bowel disease (IBD) in which the immune system attacks its own regulatory function.
New discovery renews hope for thousands with neurodevelopment disorders
12 July 2024
Children's Health Publication Research
A global collaboration led by scientists at the University of Oxford has discovered that genetic variants in a specific gene cause a rare neurodevelopmental disorder (NDD). NDD is a collective term for severe impairments in how the brain functions that impact learning, behaviour, speech, and movement. Most NDDs are thought to be genetic and caused by changes to DNA, however, to date, around 60% of individuals with these conditions do not know the specific DNA change that causes their disorder.
Research shows early life immunity increases HIV cure/remission in male infants
10 June 2024
Children's Health HIV Publication Research University
New research published by scientists at the University of Oxford, the University of KwaZulu-Natal and the Africa Health Research Institute in South Africa, and the Ragon Institute of Mass General, MIT and Harvard, USA, shows that male infants are more likely to achieve HIV cure/remission than females.
New research assesses the function of a major genetic cause of neurodevelopmental disorders
22 May 2024
Department Publication Research
New research, published today, has defined the functional impacts of hundreds of variants in a gene that is a major cause of neurodevelopmental disorders.
Ground-breaking study reveals how COVID-19 vaccines prevent severe disease
3 May 2024
COVID-19 Clinical Trials Publication Research Research Methods Vaccinology
A landmark study by scientists at the University of Oxford, has unveiled crucial insights into the way that COVID-19 vaccines mitigate severe illness in those who have been vaccinated.
New protein discovery sheds light on complexity of genetic regulation
21 February 2024
Department Publication Research
Scientists at the Department of Paediatrics have discovered a new pathway that the human body uses to silence transposable elements or ‘jumping genes’. Dr. Rebecca Berrens, Principal Investigator in the Transposon Group, has published research into the piRNA pathway, a key process our body uses to keep these transposable elements in check.
New model for infant leukaemia announced
25 November 2021
Haematology Publication Research
The breakthrough could lead to development of new treatments for infant Acute Lymphoblastic Leukaemia.
Changes in blood cell production over the human lifetime may hold clues to patterns of disease
16 September 2021
A new paper published this week in Cell Reports reveals that changes in the gene expression of blood stem cells occur across the human lifetime; an important step in the understanding and treatment of blood disorders.
Promising discovery for treatment of neuromuscular diseases
23 August 2021
Neuromuscular Diseases Publication Research
Research led by Carlo Rinaldi and Catheryn Lim discovered that a naturally-occurring isoform of an androgen receptor can be used in therapy for spinal and bulbar muscular atrophy, and shows potential for other diseases.
New book highlights life-saving role vaccines play in prevention of killer diseases
8 July 2021
Public Engagement Publication Vaccinology
'Brain Fever', a new book by internationally-renowned medical scientist Professor Richard Moxon, describes the decades of research that contribute to the development of vaccines for life-threatening illnesses such as meningitis, and how immunisation has been our greatest public health intervention.
Latest data on immune response to COVID-19 reinforces need for vaccination, says Oxford-led study
21 June 2021
COVID-19 Publication Vaccinology
A new study led by the University of Oxford has found that previous infection, whether symptomatic or asymptomatic, does not necessarily protect you long-term from COVID-19, particularly against new Variants of Concern.
Children’s pain ‘swept under the carpet for too long’ – Lancet Commission
22 October 2020
Neuroimaging Publication Research
The launch of Lancet Child and Adolescent Health Commission - the first ever to address paediatric pain - aims to raise the profile of children’s pain from early years to early adulthood.
Featured publication: Advances in oligonucleotide drug delivery
12 August 2020
Neuromuscular Diseases Publication
Oligonucleotides - short DNA or RNA molecules - have great therapeutic application for a range of diseases. Yet, their potential has not been fully unleashed because of challenges linked to efficient delivery. Read more to find out about recent developments in oligonucleotide modifications, and the platforms that may be used to deliver them to target sites.
New design of ‘bike helmet’ style brain scanner used with children for first time
7 November 2019
Neuroimaging Publication Research Methods
A new wearable ‘bike helmet’ style brain scanner, that allows natural movement during scanning, has been used in a study with young children for the first time. This marks an important step towards improving our understanding of brain development in childhood.
A call for blood and iron
1 October 2019
Dr Sarah Atkinson’s research team investigates whether an iron export mutation in African populations can protect from anaemia, malaria and bacterial infections.
First steps towards treating myotonic dystrophy type 1
11 September 2019
Collaborative research between teams from the Department of Paediatrics and the Institut de Myologie shows how antisense oligonucleotides can penetrate muscles to treat myotonic dystrophy type 1, a rare muscle disease.
The key to better childhood vaccines might be in our DNA
24 June 2019
Publication Research Vaccinology
PBS features Daniel O'Connor's research on how children's genetic profiles affect their immunity.
Blueprint Magazine features paediatric research
13 February 2019
Children's Health Clinical Trials Neuroimaging Publication
In the latest issue of the Blueprint, Shaunna Latchman meets Professor of Paediatric Neuroimaging, Rebeccah Slater to discuss the Paediatric Neuroimaging Group and find out why a gentle touch really does goes a long way.
The power of touch
18 December 2018
Neuroimaging Publication Research
Work published in Current Biology shows that lightly brushing in an infant can reduce pain-related brain activity evoked by a clinically necessary medical procedure.
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Michelle Fernandes
Clinical Lecturer & MRC Clinical Research Training Fellow
