Thomas Roberts
Senior Postdoctoral Scientist
Tom Roberts studied at the University of Oxford for both his undergraduate degree in Molecular and Cellular Biochemistry and doctoral thesis titled 'Duchenne Muscular Dystrophy: RNA-based therapeutics and microRNA biology' in the Department of Physiology, Antomy and Genetics in the laboratory of Professor Matthew Wood. He subsequently moved to San Diego, California where he undertook postdoctoral training positions at the Scripps Research Institute, Department of Molecular and Experimental Medicine (laboratory of Professors Kevin Morris and Marc Weinberg) and Sanford Burnham Prebys Medical Discovery Institute, Developement, Aging and Regeneration Program (laboratory of Professor Lorenzo Puri). He susbequently returned to the University of Oxford, Department of Paediatrics where he re-joined the Wood group. His research interests include neuromuscular disorders, RNA biology, extracellular nucleic acids, biomarkers, epigenetics, and gene/oligonucleotide therapies.
Recent publications
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Application of CRISPR-Cas9-Mediated Genome Editing for the Treatment of Myotonic Dystrophy Type 1.
Journal article
Marsh S. et al, (2020), Mol Ther
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Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle.
Journal article
Conceição M. et al, (2020), Biomaterials, 266
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Mutation-independent proteomic signatures of pathological progression in murine models of Duchenne muscular dystrophy.
Journal article
van Westering TLE. et al, (2020), Mol Cell Proteomics
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Advances in oligonucleotide drug delivery.
Journal article
Roberts TC. et al, (2020), Nat Rev Drug Discov
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GAPDH controls extracellular vesicle biogenesis and enhances therapeutic potential of EVs in silencing the Huntingtin gene in mice via siRNA delivery
Working paper
WILSON C. et al, (2020)