Senior Postdoctoral Scientist
Tom Roberts studied at the University of Oxford for both his undergraduate degree in Molecular and Cellular Biochemistry and doctoral thesis titled 'Duchenne Muscular Dystrophy: RNA-based therapeutics and microRNA biology' in the Department of Physiology, Antomy and Genetics in the laboratory of Professor Matthew Wood. He subsequently moved to San Diego, California where he undertook postdoctoral training positions at the Scripps Research Institute, Department of Molecular and Experimental Medicine (laboratory of Professors Kevin Morris and Marc Weinberg) and Sanford Burnham Prebys Medical Discovery Institute, Developement, Aging and Regeneration Program (laboratory of Professor Lorenzo Puri). He susbequently returned to the University of Oxford, Department of Paediatrics where he re-joined the Wood group. His research interests include neuromuscular disorders, RNA biology, extracellular nucleic acids, biomarkers, epigenetics, and gene/oligonucleotide therapies.
Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle.
Conceição M. et al, (2020), Biomaterials, 266
Mutation-independent proteomic signatures of pathological progression in murine models of Duchenne muscular dystrophy.
van Westering TLE. et al, (2020), Mol Cell Proteomics
Advances in oligonucleotide drug delivery.
Roberts TC. et al, (2020), Nat Rev Drug Discov
GAPDH controls extracellular vesicle biogenesis and enhances therapeutic potential of EVs in silencing the Huntingtin gene in mice via siRNA delivery
WILSON C. et al, (2020)
Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology.
van Westering TLE. et al, (2020), J Cachexia Sarcopenia Muscle, 11, 578 - 593