Senior Postdoctoral Scientist
Tom Roberts studied at the University of Oxford for both his undergraduate degree in Molecular and Cellular Biochemistry and doctoral thesis titled 'Duchenne Muscular Dystrophy: RNA-based therapeutics and microRNA biology' in the Department of Physiology, Anatomy and Genetics in the laboratory of Professor Matthew Wood. He subsequently moved to San Diego, California where he undertook postdoctoral training positions at the Scripps Research Institute, Department of Molecular and Experimental Medicine (laboratory of Professors Kevin Morris and Marc Weinberg) and Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program (laboratory of Professor Lorenzo Puri). He returned to the University of Oxford, Department of Paediatrics in 2019 where he re-joined the Wood group. His research interests include neuromuscular disorders, RNA biology, extracellular nucleic acids, biomarkers, epigenetics, and gene/oligonucleotide therapies.
AR cooperates with SMAD4 to maintain skeletal muscle homeostasis.
Forouhan M. et al, (2022), Acta Neuropathol
Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia
Laitinen P. et al, (2022), PLoS ONE, 17
Non-uniform dystrophin re-expression after CRISPR-mediated exon excision in the dystrophin/utrophin double-knockout mouse model of DMD
Hanson B. et al, (2022)
PPMO-mediated exon skipping induces uniform sarcolemmal dystrophin rescue with dose-dependent restoration of circulating microRNA biomarkers and muscle biophysical properties
Chwalenia K. et al, (2022)
Enhancing the Therapeutic Potential of Extracellular Vesicles Using Peptide Technology
Martin Perez C. et al, (2022), Methods in Molecular Biology, 2383, 119 - 141