Research Fellow / Group Leader
Tom Roberts studied at the University of Oxford for both his undergraduate degree in Molecular and Cellular Biochemistry and doctoral thesis titled 'Duchenne Muscular Dystrophy: RNA-based therapeutics and microRNA biology' in the Department of Physiology, Anatomy and Genetics in the laboratory of Professor Matthew Wood. He subsequently moved to San Diego, California where he undertook postdoctoral training positions at the Scripps Research Institute, Department of Molecular and Experimental Medicine (laboratory of Professors Kevin Morris and Marc Weinberg) and Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program (laboratory of Professor Lorenzo Puri). He returned to the University of Oxford, Department of Paediatrics in 2019 where he re-joined the Wood group.
He now leads a research group at the Institute of Development and Regenerative Medicine with the overall theme of 'RNA Medicine'. His research interests include neuromuscular disorders, RNA biology, extracellular nucleic acids, biomarkers, epigenetics, and gene/oligonucleotide therapies.
Non-uniform dystrophin re-expression after CRISPR-mediated exon excision in the dystrophin/utrophin double-knockout mouse model of DMD.
Hanson B. et al, (2022), Mol Ther Nucleic Acids, 30, 379 - 397
Exon skipping induces uniform dystrophin rescue with dose-dependent restoration of serum miRNA biomarkers and muscle biophysical properties
Chwalenia K. et al, (2022), Molecular Therapy - Nucleic Acids, 29, 955 - 968
Extracellular vesicle-mediated promotion of myogenic differentiation is dependent on dose, collection media composition, and isolation method
Hanson B. et al, (2022)
AR cooperates with SMAD4 to maintain skeletal muscle homeostasis.
Forouhan M. et al, (2022), Acta Neuropathol, 143, 713 - 731
AR cooperates with SMAD4 to maintain skeletal muscle homeostasis
Rinaldi C. et al, (2022)