We are looking for healthy adults to take part in the initial trial of a potential new vaccine against a virus considered to be a crucial missing element in the childhood vaccination programme. **Please note, this study has recruited a sufficient number of participants**

Respiratory syncytial virus (RSV) kills around 200,000 people worldwide each year. Both the elderly and infants are especially vulnerable to developing severe disease with RSV. Two-thirds of babies are infected with RSV before their first birthday and in winter the virus causes annual epidemics resulting in up to 15 out of every 100 admissions to children’s wards. In the world’s poorer areas, RSV is second only to malaria as a killer of children aged between 1 and 12 months.

In early August, the Oxford Vaccine Group, part of the University’s Department of Paediatrics, announced that the first trial of a different potential RSV vaccine had been successful. Building on the results of this study, the Group is ready to begin trials of a new version of this potential RSV vaccine.

Dr Matthew Snape from the Oxford Vaccine Group, is Chief Investigator leading the study of the new vaccine candidate. He explained: ‘Vaccine development is a long process and it is important to ensure that the best potential vaccine is taken forward for testing in larger numbers. This is why we are testing a new version of the vaccine.

‘As a paediatrician I am all too aware of the enormous burden of disease that RSV brings every winter. It is tremendously exciting to be part of an RSV vaccine programme, and the current study is an important next step towards developing a vaccine to be used in infants.’

The potential vaccine is known as a ‘viral vectored vaccine.’ That means that it uses a virus (the vector), in this case an adenovirus called ChAd155, to carry proteins from RSV that trigger the immune system to respond against it. Neither the RSV proteins nor the carrier virus can replicate and cause infection. Two injections are used: the first is expected to stimulate the immune system to prompt a response; the second is expected to strengthen the immune response triggered by the first. The complete modified product is called ChAd155-RSV.

To assess this new vaccine, the team is planning to carry out what is called a phase 1 clinical trial. In this phase, a small number of healthy adult volunteers receive the vaccine to assess whether it is safe and tolerated and it prompts the immune system to respond. If successful, it is planned that further trials will assess the effectiveness and safety of ChAd155-RSV in children – the main group who would benefit from a licensed RSV vaccine.

They are now looking for 72 volunteers from in and around Oxford, aged between 18 and 45.

To find out more visit www.ovg.ox.ac.uk/trials/RSV or call 01865 857420.



The work of the Oxford Vaccine Group is supported by the NIHR Oxford Biomedical Research Centre, and the conduct of the RSV study is being sponsored by global healthcare company GSK, who have manufactured the vaccine.

Similar stories

Fourth COVID-19 vaccine dose provides stronger immunity boost than third dose, shows UK study

COVID-19 vaccines given as fourth doses in the UK offer excellent boosting immunity protection, according to the latest results from a nationwide NIHR-supported study.

Oral paratyphoid vaccine to begin human trials

The University of Oxford in collaboration with the University of Maryland School of Medicine (UMSoM) has begun recruiting for a Phase I/II trial of a new paratyphoid vaccine in human volunteers in Oxford.

Oxford scientist named Australian of the Year in the UK

The Oxford Vaccine Group’s Lead Statistician, Professor Merryn Voysey, received the prestigious Australian of the Year in the UK award at a gala dinner recently.

Angelman syndrome: first patient to receive potential therapy in Oxford

Things that seemed impossible, only a few years ago, are happening today. The first patient in Europe and one of the first in the world was injected with a potential treatment, GTX-102, in a phase I/II clinical trial in Oxford.

New model for infant leukaemia announced

The breakthrough could lead to development of new treatments for infant Acute Lymphoblastic Leukaemia.

Why it's so hard to treat pain in infants

For decades physicians believed that premature babies didn’t experience pain. Here’s what doctors know now – and the innovative solutions being embraced by today's caregivers.