Contact information
Thomas Roberts
DPhil
Associate Professor
Tom Roberts is Associate Professor in the Department of Paediatrics, and Research Fellow at the Institute of Developmental and Regenerative Medicine at the University of Oxford. He leads the RNA Medicine research group, with interests including neuromuscular disorders, RNA biology, extracellular nucleic acids, non-coding RNA, biomarkers, epigenetics, and gene/oligonucleotide therapies. He studied at the University of Oxford for both his undergraduate degree in Molecular and Cellular Biochemistry and doctoral degree in Physiology, Anatomy and Genetics. He subsequently undertook postdoctoral training positions at the Scripps Research Institute and Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California, USA.
He is a member of the American Society for Gene and Cell Therapy (ASGCT) and the British Society for Gene and Cell Therapy (BSGCT) and holds visiting positions at the Karolinska Institute (Stockholm, Sweden) and the National Center of Neurology and Psychiatry (NCNP, Tokyo, Japan). He serves on the editorial boards of Molecular Therapy – Nucleic Acids and Gene Therapy. In 2022 he founded a biotech start-up company, Orfonyx Bio, that aims to develop genetic medicines for rare diseases.
Recent publications
Myonuclear Domain-Associated and Central Nucleation-Dependent Spatial Restriction of Dystrophin Protein Expression.
Journal article
Chwalenia K. et al, (2026), J Cachexia Sarcopenia Muscle, 17
Targeted BDNF upregulation via upstream open reading frame disruption.
Journal article
Feng N. et al, (2026), Mol Ther, 34, 1652 - 1671
Timing matters: exon skipping therapy is most effective when initiated early in a mouse model of Duchenne muscular dystrophy
Preprint
Stenler S. et al, (2025)
Progress and prospects in antisense oligonucleotide-mediated exon skipping therapies for Duchenne muscular dystrophy.
Journal article
Chwalenia K. et al, (2025), J Muscle Res Cell Motil, 46, 293 - 300
AAV microdystrophin gene replacement therapy for Duchenne muscular dystrophy: progress and prospects.
Journal article
Chwalenia K. et al, (2025), Gene Ther, 32, 447 - 461