Contact information
Thomas Roberts
DPhil
Associate Professor
Tom Roberts is Associate Professor in the Department of Paediatrics, and Research Fellow at the Institute of Developmental and Regenerative Medicine at the University of Oxford. He leads the RNA Medicine research group, with interests including neuromuscular disorders, RNA biology, extracellular nucleic acids, non-coding RNA, biomarkers, epigenetics, and gene/oligonucleotide therapies. He studied at the University of Oxford for both his undergraduate degree in Molecular and Cellular Biochemistry and doctoral degree in Physiology, Anatomy and Genetics. He subsequently undertook postdoctoral training positions at the Scripps Research Institute and Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California, USA.
He is a member of the American Society for Gene and Cell Therapy (ASGCT) and the British Society for Gene and Cell Therapy (BSGCT) and holds visiting positions at the Karolinska Institute (Stockholm, Sweden) and the National Center of Neurology and Psychiatry (NCNP, Tokyo, Japan). He serves on the editorial boards of Molecular Therapy – Nucleic Acids and Gene Therapy. In 2022 he founded a biotech start-up company, Orfonyx Bio, that aims to develop genetic medicines for rare diseases.
Recent publications
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AAV microdystrophin gene replacement therapy for Duchenne muscular dystrophy: progress and prospects.
Chwalenia K. et al, (2025), Gene Ther
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Myonuclear domain-associated and central nucleation-dependent spatial restriction of dystrophin protein expression in a novel DMD mouse model
Chwalenia K. et al, (2025)
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Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors.
Liang X. et al, (2025), Nat Commun, 16
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Targeted BDNF upregulation via upstream open reading frame disruption
Feng N. et al, (2025)
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uORF-targeting steric block antisense oligonucleotides do not reproducibly increase RNASEH1 expression
Ahlskog N. et al, (2025), Molecular Therapy - Nucleic Acids, 36, 102406 - 102406