Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Research groups

Yulia Lomonosova

Postdoctoral Research Scientist

My primary focus in Wood group is development of combination therapeutics for Duchenne Muscular Dystrophy (DMD) involving manipulation of pre-mRNA splicing using antisense oligonucleotides (ASO) to correct aberrant reading frame and translate functional dystrophin protein. Particularly, since dystrophin is a large sub-sarcolemmal protein, I study plasma membrane in dystrophic muscle and after its treatment with ASO to identify novel drivers of disease and putative therapeutic targets. In parallel, I am investigating the role of eEF2k/eEF2 and PI3K/mTOR/p70S6k signaling pathways in a marked reduction of protein synthesis rate in DMD muscle and in case of muscle wasting.

Biography. I completed my PhD program at the Institute of Bio-medical Problems, Russian Academy of Sciences, Moscow, focusing on prevention of atrophy development during space flight and hypokinesia utilizing microgravity models, in particular, head-out dry immersion in humans and hindlimb suspension of rodents. I investigated signaling pathways involved in regulation of proteolysis (calpains, E3-ubiquitin ligases) and protein synthesis (IGF-1/mTOR/p70S6k) in skeletal muscle upon disuse and eccentric exercise. I was recognised as a laureate of the RF President’s Prize in the field of science and innovations for young scientists. In collaboration with NASA and Neuromuscular Group, Charité – University Medicine Berlin, I continued my research in the investigation of fast-to-slow transition of skeletal muscle contractile function under microgravity. In 2017, I joined the lab of Prof. Matthew Wood at the University of Oxford as a Postdoctoral Research Scientist in Muscle Biology.