Patricia Gonzalez Dias Carvalho
Patricia holds a Master’s Degree in Cellular and Molecular Biology from Instituto Oswaldo Cruz (Fiocruz, Brazil) followed by PhD in Physiopathology and Toxicology at the University of Sao Paulo.
In her master’s degree she studied the immune response induced by different adjuvants and its application in the development of subunit vaccines in the pre-clinical phase. While in her PhD she started to work as a Computational Biologist. She has been working since then on integrative analyses of immunomic, transcriptomic and reactogenic data using systems biology and machine learning approaches to decipher the immune and molecular signatures of the human response elicited by different vaccines and infections.
She joined OVG in 2022 and has been working mainly with respiratory infections disease using data from Experimental Human Challenge Platform. Her main focus at the moment is to identify immune correlates of protection to Pneumococcal infection.
Comprehensive review of safety in Experimental Human Pneumococcal Challenge
Robinson RE. et al, (2023), PLOS ONE, 18, e0284399 - e0284399
Human Infection Challenge with Serotype 3 Pneumococcus.
Robinson RE. et al, (2022), Am J Respir Crit Care Med, 206, 1379 - 1392
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination.
Pannaraj PS. et al, (2022), Mucosal Immunol, 15, 1040 - 1047
Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study.
Vianello E. et al, (2022), Lancet Microbe, 3, e113 - e123
In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19
ten-Caten F. et al, (2021), International Journal of Infectious Diseases, 105, 579 - 587