MA (Oxon), MD, FMedSci, FRCPCH, FMH Paediatrics (CH)
Hoffmann and Action Medical Research Professor of Developmental Medicine
- Head of Department
Understanding the development and function of the immune system in health and disease
Prof. Georg A Holländer was trained in both Paediatrics and Experimental Immunology in Switzerland and the U.S. He held academic positions at Harvard Medical School, Boston, U.S. and the University of Basel, Switzerland, before he joined the University of Oxford, UK (2010). He is interested in the development and function of the immune system in health and disease. His particular scientific focus concerns the molecular and cellular control of thymus development and function.
Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.
Mayer CE. et al, (2016), Eur J Immunol, 46, 846 - 856
Open Access Could Transform Drug Discovery: A Case Study of JQ1.
Arshad Z. et al, (2016), Expert Opin Drug Discov, 11, 321 - 332
The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility
Tang F. et al, (2015), Science Signaling, 8, ra100 - ra100
A subpopulation of CD103(pos) ICOS(pos) Treg cells occurs at high frequency in lymphopenic mice and represents a lymph node specific differentiation stage.
Barthlott T. et al, (2015), Eur J Immunol, 45, 1760 - 1771
Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells in acute GVHD.
Dertschnig S. et al, (2015), Blood, 125, 2720 - 2723