Georg Holländer

• T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.

  Smith MJ. et al, (2017), JCI Insight, 2

• Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.

  Žuklys S. et al, (2016), Nature Immunology

• Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development

  Hollander GAP., (2016), Nature Immunology

• Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.

  Mayer CE. et al, (2016), Eur J Immunol, 46, 846 - 856

• The Limitations of QALY: A Literature Review

  Pettitt DA. et al, (2016), Journal of Stem Cell Research & Therapy

• Open Access Could Transform Drug Discovery: A Case Study of JQ1.

  Arshad Z. et al, (2016), Expert Opin Drug Discov, 11, 321 - 332

• The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

  Tang F. et al, (2015), Science Signaling, 8, ra100 - ra100

• A subpopulation of CD103(pos) ICOS(pos) Treg cells occurs at high frequency in lymphopenic mice and represents a lymph node specific differentiation stage.

  Barthlott T. et al, (2015), Eur J Immunol, 45, 1760 - 1771

• Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells in acute GVHD.

  Dertschnig S. et al, (2015), Blood, 125, 2720 - 2723

• A subpopulation of CD103<sup>pos</sup>ICOS<sup>pos</sup> Treg cells occurs at high frequency in lymphopenic mice and represents a lymph node specific differentiation stage

  Barthlott T. et al, (2015), European Journal of Immunology, 45, 1760 - 1771

• Essential role for autophagy during invariant NKT cell development.

  Salio M. et al, (2014), Proc Natl Acad Sci U S A, 111, E5678 - E5687

• Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.

  Sansom SN. et al, (2014), Genome Res, 24, 1918 - 1931

• A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.

  Hauri-Hohl M. et al, (2014), Nat Immunol, 15, 554 - 561

• Lentiviral Vector-Mediated Induction of Oct4 Expression in Primary Adult Mouse Thymic Epithelial Cells To Generate Tools for Gene Replacement and Tissue Regeneration

  Bosticardo M. et al, (2014), MOLECULAR THERAPY, 22, S264 - S265

• IMPAIRED THYMIC EXPRESSION OF A TISSUE-RESTRICTED ANTIGEN LICENSES THE DE NOVO GENERATION OF AUTOREACTIVE CD4+T CELLS DURING MURINE ACUTE GRAFT-VERSUS-HOST DISEASE

  Dertschnig S. et al, (2014), BONE MARROW TRANSPLANTATION, 49, S20 - S21

• A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

  Hauri-Hohl M. et al, (2014), Nature Immunology, 15, 554 - 561

• TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.

  Jenkinson SR. et al, (2013), Proc Natl Acad Sci U S A, 110, 21107 - 21112

• TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice.

  Odaka C. et al, (2013), Int Immunol, 25, 633 - 642

• Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD.

  Dertschnig S. et al, (2013), Blood, 122, 837 - 841

• IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.

  Shitara S. et al, (2013), J Immunol, 190, 6173 - 6179

• Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.

  Ohigashi I. et al, (2013), Proc Natl Acad Sci U S A, 110, 9885 - 9890

• MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.

  Zuklys S. et al, (2012), J Immunol, 189, 3894 - 3904

• LENTIVIRAL TRANSDUCTION OF PRIMARY ADULT MOUSE THYMIC EPITHELIAL CELLS TO CREATE CELLS COMPETENT TO SUPPORT REGULAR THYMOPOIESIS BOTH IN VITRO AND IN VIVO

  Bosticardo M. et al, (2012), JOURNAL OF CLINICAL IMMUNOLOGY, 32, 11 - 11

• GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.

  Lopez-Rios J. et al, (2012), Dev Cell, 22, 837 - 848

• The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.

  Papadopoulou AS. et al, (2011), Nat Immunol, 13, 181 - 187

• CD43 regulates the threshold for T cell activation by targeting Cbl functions.

  Pedraza-Alva G. et al, (2011), IUBMB Life, 63, 940 - 948

• Thymic T-cell development in allogeneic stem cell transplantation.

  Krenger W. et al, (2011), Blood, 117, 6768 - 6776

• Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.

  Lei Y. et al, (2011), J Exp Med, 208, 383 - 394

• Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity

  Gossens K. et al, (2010), PLoS ONE, 5, 1 - 9

• Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity.

  Gossens K. et al, (2010), PLoS One, 5

• Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent control.

  Fayard E. et al, (2010), Sci Signal, 3

• Emerging strategies to boost thymic function.

  Holländer GA. et al, (2010), Curr Opin Pharmacol, 10, 443 - 453

• The role of the thymus in allogeneic hematopoietic stem cell transplantation.

  Krenger W. and Holländer GA., (2010), Swiss Med Wkly, 140

• The role of the thymus in allogeneic haematopoietic stem cell transplantation

  Krenger W. and Hollaender GA., (2010), SWISS MEDICAL WEEKLY, 140, 12 - 22

• The role of the thymus in allogeneic haematopoietic stem cell transplantation

  Krenger W. and Holländer GA., (2010), Swiss Medical Weekly, 140

• The role of the mTor pathway for the development of the mouse thymic epithelium and function

  Berkemeier C. et al, (2010), SWISS MEDICAL WEEKLY, 140, 41S - 41S

• Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation.

  Kelly RM. et al, (2010), Blood, 115, 1088 - 1097

• Thymic cysts originate from Foxn1 positive thymic medullary epithelium.

  Vroegindeweij E. et al, (2010), Mol Immunol, 47, 1106 - 1113

• Spatial (Tbata) expression in mature medullary thymic epithelial cells.

  Saade M. et al, (2010), Eur J Immunol, 40, 530 - 538

• The role of the thymus in hematopoietic stem cell transplantation

  Krenger W. and Holländer GA., (2010), Bone Marrow Transplantation Across Major Genetic Barriers, 1 - 492

• Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis.

  Kenins L. et al, (2010), Eur J Immunol, 40, 81 - 90

• Clearing the AIRE: on the pathophysiological basis of the autoimmune polyendocrinopathy syndrome type-1.

  Shikama N. et al, (2009), Endocrinol Metab Clin North Am, 38, 273 - vii

• The Global Thymus Network: past, present and future.

  Takahama Y. et al, (2009), Trends Immunol, 30, 191 - 192

• Learning to be tolerant: how T cells keep out of trouble.

  Holländer GA. and Peterson P., (2009), J Intern Med, 265, 541 - 561

• Autoantigen-specific interactions with CD4+thymocytes control mature medullary thymic epithelial cell cellularity

  Irla M. et al, (2009), SWISS MEDICAL WEEKLY, 139, 16S - 16S

• Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.

  Zuklys S. et al, (2009), J Immunol, 182, 2997 - 3007

• The immunopathology of thymic GVHD.

  Krenger W. and Holländer GA., (2008), Semin Immunopathol, 30, 439 - 456

• Lymphoid reconstitution following hematopoietic stem cell transplantation. Of mice and men: progress made in HSCT immunobiology.

  Holländer GA., (2008), Semin Immunopathol, 30, 369 - 370

• Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.

  Jeker LT. et al, (2008), Blood, 112, 3688 - 3695

• Delta-like 4 is indispensable in thymic environment specific for T cell development.

  Hozumi K. et al, (2008), J Exp Med, 205, 2507 - 2513

• Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.

  Irla M. et al, (2008), Immunity, 29, 451 - 463

• TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.

  Hauri-Hohl MM. et al, (2008), Blood, 112, 626 - 634

• TGF- 2signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution

  Hauri-Hohl MM. et al, (2008), Blood, 112, 626 - 634

• Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation.

  Kelly RM. et al, (2008), Blood, 111, 5734 - 5744

• The thymus in GVHD pathophysiology.

  Krenger W. and Holländer GA., (2008), Best Pract Res Clin Haematol, 21, 119 - 128

• Overexpression of lymphotoxin in T cells induces fulminant thymic involution.

  Heikenwalder M. et al, (2008), Am J Pathol, 172, 1555 - 1570

• Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation.

  Kenins L. et al, (2008), J Exp Med, 205, 523 - 531

• Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen.

  Alimohammadi M. et al, (2008), N Engl J Med, 358, 1018 - 1028

• Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor.

  Guimond M. et al, (2008), Blood, 111, 969 - 970

• Sonic Hedgehog regulates thymic epithelial cell differentiation

  Saldana JI. et al, Journal of Autoimmunity

• Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells

  Satoh R. et al, PLoS Genetics

• Regulatory Barriers to the Advancement of Precision Medicine

  Pettitt DA. et al, Expert Review of Precision Medicine and Drug Development

• Evolution of the immune system in humans from infancy to old age

  Simon AK. et al, Proceedings B of Royal Society

• adult thymic medullary epithelium is maintained and regenerated by linage-restricted cells rather than bipotent progenitors

  Ohigashi I. et al, Cell Reports

Recent Publications

• T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.

  Smith MJ. et al, (2017), JCI Insight, 2

• Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.

  Žuklys S. et al, (2016), Nature Immunology

• Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development

  Hollander GAP., (2016), Nature Immunology

• Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.

  Mayer CE. et al, (2016), Eur J Immunol, 46, 846 - 856

• The Limitations of QALY: A Literature Review

  Pettitt DA. et al, (2016), Journal of Stem Cell Research & Therapy