MA (Oxon), MD, FMedSci, FRCPCH, FMH Paediatrics (CH)
Hoffmann and Action Medical Research Professor of Developmental Medicine
- Head of Department
Understanding the development and function of the immune system in health and disease
Prof. Georg A Holländer was trained in both Paediatrics and Experimental Immunology in Switzerland and the U.S. He held academic positions at Harvard Medical School, Boston, U.S. and the University of Basel, Switzerland, before he joined the University of Oxford, UK (2010). He is interested in the development and function of the immune system in health and disease. His particular scientific focus concerns the molecular and cellular control of thymus development and function.
Cadherin 17 mutation associated with leaky severe combined immune deficiency is corrected by HSCT.
Smith AR. et al, (2017), Blood advances, 1, 2083 - 2087
T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.
Smith MJ. et al, (2017), JCI insight, 2
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.
Žuklys S. et al, (2016), Nature Immunology
Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development
Hollander GAP., (2016), Nature Immunology
The increase in thymopoiesis following T cell progenitor therapy is dependent upon the input population and continued interaction between developing T cells and the thymic microenvironment.
Smith MJ. et al, (2016), JOURNAL OF IMMUNOLOGY, 196