MA (Oxon), MD, FMedSci, FRCPCH, FMH Paediatrics (CH)
Hoffmann and Action Medical Research Professor of Developmental Medicine
- Head of Department
Understanding the development and function of the immune system in health and disease
Prof. Georg A Holländer was trained in both Paediatrics and Experimental Immunology in Switzerland and the U.S. He held academic positions at Harvard Medical School, Boston, U.S. and the University of Basel, Switzerland, before he joined the University of Oxford, UK (2010). He is interested in the development and function of the immune system in health and disease. His particular scientific focus concerns the molecular and cellular control of thymus development and function.
Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis.
Wendland K. et al, (2018), J Immunol
Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development.
Stefanski HE. et al, (2018), PLoS One, 13
Cadherin 17 mutation associated with leaky severe combined immune deficiency is corrected by HSCT.
Smith AR. et al, (2017), Blood advances, 1, 2083 - 2087
T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.
Smith MJ. et al, (2017), JCI insight, 2
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.
Žuklys S. et al, (2016), Nature Immunology