Senior Post Doctoral Researcher
I am a BRC and James Martin School funded Post Doctoral Researcher in the OVG lab, mainly working on B cell studies based around the clinical trials. Prior to working in OVG I completed and MSc in Immunology at Kings College London, followed by an 18 month post as a Guest Researcher in the Respiratory Diseases Branch at CDC in Atlanta. I completed my PhD with Andy at OVG, finishing in 2008. My main focus now is on B cell responses to vaccine antigens and I have developed assays to identify antigen specific B cells by ELISpot and Flow Cytometry. This work has been applied to studies both in the UK and in Fiji where the data are being used to help optimise pneumococcal vaccine schedules.
Pneumococcal conjugate and plain polysaccharide vaccines have divergent effects on antigen-specific B cells.
Clutterbuck EA. et al, (2012), J Infect Dis, 205, 1408 - 1416
Comparison of a limiting dilution assay and ELISpot for detection of memory B-cells before and after immunisation with a protein-polysaccharide conjugate vaccine in children.
Blanchard-Rohner G. et al, (2010), J Immunol Methods, 358, 46 - 55
Kinetics of the natural, humoral immune response to Salmonella enterica serovar Typhi in Kathmandu, Nepal.
Pulickal AS. et al, (2009), Clin Vaccine Immunol, 16, 1413 - 1419
Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal polysaccharide vaccine.
Kelly DF. et al, (2009), Immunology, 127, 134 - 143
Serotype-specific and age-dependent generation of pneumococcal polysaccharide-specific memory B-cell and antibody responses to immunization with a pneumococcal conjugate vaccine.
Clutterbuck EA. et al, (2008), Clin Vaccine Immunol, 15, 182 - 193