Daniel O'Connor
BSc AFHEA MSc DPhil (OXON)
University Research Lecturer | Head of Bioinformatics
Daniel has both a wet-laboratory and bioinformatics background, his main research interests relate to the analysis of contemporary, high-dimensional datasets (e.g. genomic, transcriptomic, proteomic) to elucidate the molecular determinants of vaccine responses.
UTILISING THE SYSTEMS TOOLKIT TO ELUCIDATE THE MECHANISMS UNDERLYING RESPONSES TO INFANT IMMUNISATION
Vaccine responses and the persistence of vaccine-immunity vary considerably between individuals, this is particularly relevant in childhood, as infants generally have lower magnitude immune responses that wane more rapidly than adults. My research utilises contemporary methods, such as genome-wide genotyping and next-generation sequencing, to explore the mechanisms underlying immunological and physiological responses to childhood vaccinations.
Key publications
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Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine.
Journal article
O'Connor D. et al, (2020), Mol Syst Biol, 16
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Common Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization.
Journal article
O'Connor D. et al, (2019), Cell Rep, 27, 3241 - 3253.e4
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RNA2HLA: HLA-based quality control of RNA-seq datasets
Journal article
Chelysheva I. et al, (2021), Briefings in Bioinformatics
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The effect of H1N1 vaccination on serum miRNA expression in children: A tale of caution for microRNA microarray studies.
Journal article
Drury RE. et al, (2019), PLoS One, 14
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High-dimensional assessment of B-cell responses to quadrivalent meningococcal conjugate and plain polysaccharide vaccine.
Journal article
O'Connor D. et al, (2017), Genome Med, 9
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Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination.
Journal article
Pischedda S. et al, (2021), Clin Epigenetics, 13
Recent publications
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Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection.
Journal article
Mentzer AJ. et al, (2022), Nat Med
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Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19.
Journal article
Kotanidis CP. et al, (2022), Lancet Digit Health
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Clinical and Viral Factors Associated With Disease Severity and Subsequent Wheezing in Infants With Respiratory Syncytial Virus Infection.
Journal article
McGinley JP. et al, (2022), J Infect Dis