Research groups
Daniel O'Connor
BSc MSc DPhil
Postdoctoral Researcher
Daniel has both a wet-laboratory and bioinformatics background, his main research interests relate to the analysis of contemporary, high-dimensional datasets (e.g. genomic, transcriptomic, proteomic) to elucidate the molecular determinants of vaccine responses.
UTILISING THE SYSTEMS TOOLKIT TO ELUCIDATE THE MECHANISMS UNDERLYING RESPONSES TO INFANT IMMUNISATION
Vaccine responses and the persistence of vaccine-immunity vary considerably between individuals, this is particularly relevant in childhood, as infants generally have lower magnitude immune responses that wane more rapidly than adults. My research utilises contemporary methods, such as genome-wide genotyping and next-generation sequencing, to explore the mechanisms underlying immunological and physiological responses to childhood vaccinations.
Key publications
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Common Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization.
Journal article
O'Connor D. et al, (2019), Cell Rep, 27, 3241 - 3253.e4
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Characterizing vaccine responses using host genomic and transcriptomic analysis.
Journal article
O'Connor D. and Pollard AJ., (2013), Clin Infect Dis, 57, 860 - 869
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High-dimensional assessment of B-cell responses to quadrivalent meningococcal conjugate and plain polysaccharide vaccine.
Journal article
O'Connor D. et al, (2017), Genome Med, 9
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The effect of chronic cytomegalovirus infection on pneumococcal vaccine responses.
Journal article
O'Connor D. et al, (2014), J Infect Dis, 209, 1635 - 1641
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The Clinical Application of MicroRNAs in Infectious Disease.
Journal article
Drury RE. et al, (2017), Frontiers in Immunology, 8, 1182 - 1182
Recent publications
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Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.
Journal article
Folegatti PM. et al, (2020), Lancet, 396, 467 - 478
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Simultaneous Viral Whole-Genome Sequencing and Differential Expression Profiling in Respiratory Syncytial Virus Infection of Infants.
Journal article
Lin G-L. et al, (2020), J Infect Dis
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Immunogenicity and Reactogenicity of a Reduced Schedule of a 4-component Capsular Group B Meningococcal Vaccine: A Randomized Controlled Trial in Infants.
Internet publication
Valente Pinto M. et al, (2020), 7
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Effects of technical noise on bulk RNA-seq differential gene expression inference
Journal article
Sheerin D. et al, (2019)
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Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome
Journal article
O'Byrne SI. et al, (2019), Blood, 134, 1206 - 1206