BSc MSc DPhil
Daniel has both a wet-laboratory and bioinformatics background, his main research interests relate to the analysis of contemporary, high-dimensional datasets (e.g. genomic, transcriptomic, proteomic) to elucidate the molecular determinants of vaccine responses.
UTILISING THE SYSTEMS TOOLKIT TO ELUCIDATE THE MECHANISMS UNDERLYING RESPONSES TO INFANT IMMUNISATION
Vaccine responses and the persistence of vaccine-immunity vary considerably between individuals, this is particularly relevant in childhood, as infants generally have lower magnitude immune responses that wane more rapidly than adults. My research utilises contemporary methods, such as genome-wide genotyping and next-generation sequencing, to explore the mechanisms underlying immunological and physiological responses to childhood vaccinations.
Effects of technical noise on bulk RNA-seq differential gene expression inference
Sheerin D. et al, (2019)
Comparative transcriptomics between species attributes reactogenicity pathways induced by the capsular group B meningococcal vaccine, 4CMenB, to the membrane-bound endotoxin of its outer membrane vesicle component.
Sheerin D. et al, (2019), Sci Rep, 9
Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leucocyte antigen locus.
Parks T. et al, (2019), Genes Immun
Host genetic variants near the PAX5 gene locus associate with susceptibility to invasive group A streptococcal disease
Parks T. et al, (2019)
Common Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization.
O'Connor D. et al, (2019), Cell Rep, 27, 3241 - 3253.e4