MMath MRes PhD
Caroline's research investigates how sensory information is processed in infants, particularly focusing on the development of pain processing. Her research combines neuroimaging and neurophysiological techniques (Electroencephalography - EEG - and functional Magnetic Resonance Imaging - fMRI) with the aim of improving future pain management in infants.
Caroline completed her undergraduate degree in Mathematics at the University of Warwick in 2008. She then joined the Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, first undertaking a masters degree in Mathematical Biology before carrying on to do a PhD. Her PhD research examined brain development in preterm babies. Specifically, her research investigated the patterning of bursts of activity observed in EEG recordings of preterm babies. She also used computational neural network models to explore how neuronal connections form in the developing brain.
A blinded randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants: Trial protocol.
Slater R. et al, (2016), Wellcome Open Res, 1, 7 - 7
Changing balance of spinal cord excitability and nociceptive brain activity in early human development
Hartley C. et al, (2016), Current Biology
Electroencephalography during general anaesthesia differs between term-born and premature-born children.
Poorun R. et al, (2016), Clin Neurophysiol, 127, 1216 - 1222
Protocol 15PRT/5747: A blinded randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants
Hartley C. et al, (2016), Lancet
The relationship between nociceptive brain activity, spinal reflex withdrawal and behaviour in newborn infants.
Hartley C. et al, (2015), Sci Rep, 5