Inflammatory disease microbiomes share a functional pathogenicity predicted by C-reactive protein.
Britton GJ. et al, (2025), bioRxiv
Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes.
Thompson KN. et al, (2023), Sci Transl Med, 15
C5a and C5aR are elevated in joints of rheumatoid and psoriatic arthritis patients, and C5aR blockade attenuates leukocyte migration to synovial fluid.
Hornum L. et al, (2017), PLoS One, 12
Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis.
Söderström K. et al, (2010), Proc Natl Acad Sci U S A, 107, 13028 - 13033
Natural killer cells trigger differentiation of monocytes into dendritic cells.
Zhang AL. et al, (2007), Blood, 110, 2484 - 2493
Qa-1b-Dependent modulation cross-talk in vivo
Colmenero P. et al, (2007), JOURNAL OF IMMUNOLOGY, 179, 4608 - 4615