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Publications

Developmental stage- and site-specific transitions in lineage specification and gene regulatory networks in human hematopoietic stem and progenitor cells

ROY A. et al, (2021), bioRxiv

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.

Muskens IS. et al, (2021), Nat Commun, 12

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

Louka E. et al, (2021), J Exp Med, 218

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.

Godfrey L. et al, (2021), Leukemia, 35, 90 - 106

A novel human fetal liver-derived model reveals that MLL-AF4 drives a distinct fetal gene expression program in infant ALL

Rice S. et al, (2020), bioRxiv

Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome.

Cruz Hernandez D. et al, (2020), Blood, 136, 1460 - 1465

Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome

O'Byrne SI. et al, (2019), BLOOD, 134

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs.

O'Byrne S. et al, (2019), Blood, 134, 1059 - 1071

Most haematological abnormalities in neonates with Down syndrome are transient but dysplastic myelopoiesis persists throughout early childhood

Hanssen L. et al, (2019), BRITISH JOURNAL OF HAEMATOLOGY, 185, 106 - 106

Single-cell profiling reveals key differences in the cellular architecture of human haematopoietic stem and progenitor cells throughout fetal and adult life

ROY A. et al, (2018)

Mature Analysis of the Prospective Oxford Down Syndrome (DS) Cohort Study: Timing and Clinical Impact of Preleukemic GATA1 Mutations and Lessons for Management of Newborns with DS

Roberts I. et al, (2017), BLOOD, 130

Molecular and Functional Characterization of Disease-Propagating Stem Cells in Juvenile Myelomonocytic Leukemia

Louka E. et al, (2017), BLOOD, 130

RE-ORDERING THE B CELL DEVELOPMENT HIERARCHY IN HUMAN FETAL BONE MARROW: CHARACTERISATION OF A NOVEL HUMAN FETAL B PROGENITOR

O'Byrne S. et al, (2017), HAEMATOLOGICA, 102, 80 - 80

GENOME WIDE DYSREGULATION OF GENE EXPRESSION BY TRISOMY 21 IN FETAL LIVER HAEMATOPOIETIC STEM AND PROGENITOR CELLS

Roy A. et al, (2016), HAEMATOLOGICA, 101, 120 - 120

Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.

Goodings C. et al, (2015), Stem Cells, 33, 2628 - 2641

Enforced expression of E47 has differential effects on Lmo2-induced T-cell leukemias

Goodings C. et al, (2015), Leukemia Research, 39, 100 - 109

Clinical and Hematologic Impact of Fetal and Perinatal Variables on Mutant GATA1 Clone Size in Neonates with Down Syndrome

Bhatnagar N. et al, (2014), BLOOD, 124

LMO2 induces T-cell leukemia with epigenetic deregulation of CD4

Cleveland SM. et al, (2014), Experimental Hematology, 42, 581 - 593.e5

Hhex Is a Critical Gene In The Development Of Normal and Malignant Lymphoid Cells

Goodings C. et al, (2013), Blood, 122, 3788 - 3788

FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma

Elliott NE. et al, (2011), Blood, 118, 3911 - 3921

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Michelle Fernandes

Clinical Lecturer & MRC Clinical Research Training Fellow

Include forthcoming?