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Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4-22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4-22 (anti-res4-22), mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti-res4-22 was found significantly more often (47.4%) than in the total group of neurological patients. Anti-res4-22 positive sera showed significantly more frequently myelin staining in cerebellum and nerve sections than anti-res4-22 negative sera. Our findings demonstrate a new species of human autoantibodies against a newly described protein the function of which is still unknown.

Type

Journal article

Journal

Scand J Immunol

Publication Date

02/2001

Volume

53

Pages

204 - 208

Keywords

Autoantibodies, Autoantigens, Autoimmune Diseases of the Nervous System, Brain Ischemia, Cerebellum, Chromosomes, Human, Pair 4, Gene Library, Genes, Humans, Huntingtin Protein, Immunoglobulin A, Intestinal Mucosa, Intestine, Small, Microscopy, Fluorescence, Muscle, Smooth, Myelin Sheath, Nerve Tissue Proteins, Nervous System Diseases, Nuclear Proteins, Proteins, Schwann Cells, Sequence Homology, Nucleic Acid