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OBJECTIVE: To evaluate whether taking into account anti-deamidated gliadin peptide (DGP) antibody concentrations improves clinical interpretation. DESIGN AND METHODS: We calculated likelihood ratios (LR) using data from two previously published studies for assays from EUROIMMUN and INOVA. RESULTS: LRs markedly increased with increasing IgG anti-DGP concentrations. LRs also increased with increasing IgA anti-DGP concentrations, although they were lower than for IgG anti-DGP. CONCLUSIONS: Use of LRs for different test result intervals improves clinical interpretation.

Original publication

DOI

10.1016/j.clinbiochem.2010.09.026

Type

Journal article

Journal

Clin Biochem

Publication Date

02/2011

Volume

44

Pages

248 - 250

Keywords

Adult, Celiac Disease, Child, Gliadin, Humans, Immunoglobulin A, Immunoglobulin G, Transglutaminases