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Viral vectors are the vaccine platform of choice for many pathogens that have thwarted efforts towards control using conventional vaccine approaches. Although the STEP trial encumbered development of recombinant human adenovirus vectors only a few years ago, replication-deficient simian adenoviruses have since emerged as a crucial component of clinically effective prime-boost regimens. The vectors discussed here elicit functionally relevant cellular and humoral immune responses, at extremes of age and in diverse populations. The recent Ebola virus outbreak highlighted the utility of viral vectored vaccines in facilitating a rapid response to public health emergencies. Meanwhile, technological advances in manufacturing to support scale-up of viral vectored vaccines have helped to consolidate their position as a leading approach to tackling 'old' and emerging infections.

Original publication

DOI

10.1016/j.coi.2016.05.014

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

08/2016

Volume

41

Pages

47 - 54

Keywords

Animals, Genetic Vectors, Humans, Immunogenicity, Vaccine, Viral Vaccines