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OBJECTIVE: The purpose of this study was to investigate whether purified CD34(+) cells from first-trimester fetal blood are a source of primitive and committed hemopoietic progenitors. STUDY DESIGN: CD34(+) cells from first-trimester fetal blood and term cord blood were assayed for committed hemopoietic progenitor cells, high proliferative potential colony-forming cells, and long-term culture-initiating cells. RESULTS: First-trimester CD34(+) cells that were compared with cells at term generated fewer hemopoietic progenitor cells and fewer high proliferative potential colony-forming cells with lower recloning efficiency(P

Original publication

DOI

10.1067/mob.2003.236

Type

Journal article

Journal

Am J Obstet Gynecol

Publication Date

04/2003

Volume

188

Pages

1002 - 1010

Keywords

Antigens, CD34, Blood Cells, Cells, Cultured, Colony-Forming Units Assay, Female, Fetal Blood, Hematopoietic Stem Cells, Humans, Pregnancy, Pregnancy Trimester, First, Time Factors