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The minichromosome maintenance (Mcm) and Cdc6 proteins are important regulators of eucaryotic DNA replication. In most normal tissues, a similar proportion of cells express Mcm-2 and Ki-67. The present study showed that in both normal and abnormal states, the proportion of megakaryocytes expressing Mcm-2 is roughly seven times as many as those that express Ki-67. This is likely to be related to the process of endomitosis and endoreduplication. We also demonstrated that a significantly lower proportion of megakaryocytes in myelodysplastic syndrome express Mcm-2. These findings provide new insights into megakaryocyte biology.

Original publication

DOI

10.1111/j.1365-2141.2005.05801.x

Type

Journal article

Journal

Br J Haematol

Publication Date

11/2005

Volume

131

Pages

490 - 494

Keywords

Bone Marrow, Cell Cycle Proteins, Cell Nucleus, Cytoplasm, Erythroid Precursor Cells, Humans, Integrin beta3, Ki-67 Antigen, Megakaryocytes, Minichromosome Maintenance Complex Component 2, Myelodysplastic Syndromes, Myeloproliferative Disorders, Nuclear Proteins