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Although the feasibility of using HLA-mismatched unrelated donors as an alternate graft source for haematopoietic SCT (HSCT) has been shown, little is known about the safety of HLA-mismatched DLI for the treatment of relapse. We examined the outcome of 58 consecutive leukaemia patients who received escalating-dose DLI for treatment of relapse after alemtuzumab-conditioned myeloablative unrelated donor HSCT at our institution. High-resolution HLA typing on stored DNA samples revealed mismatches in 28/58 patients who were considered HLA-matched at the time of transplantation. Following DLI from HLA-matched (10/10) (n=30) or -mismatched (7-9/10) (n=28) unrelated donors, we found no significant difference in the incidence of acute GVHD (17.2% versus 23.1%, P=0.59), probability of remission at 3 years (62.1% versus 63.9%, P=0.89) or 5-year OS (89.8% versus 77.7%, P=0.22). We conclude that escalating-dose DLI can be safely given to HLA-mismatched recipients following T-depleted myeloablative HSCT.

Original publication

DOI

10.1038/bmt.2013.69

Type

Journal article

Journal

Bone Marrow Transplant

Publication Date

10/2013

Volume

48

Pages

1324 - 1328

Keywords

Adolescent, Adult, Alemtuzumab, Antibodies, Monoclonal, Humanized, Female, HLA Antigens, Histocompatibility, Humans, Leukemia, Male, Middle Aged, Neoplasm Recurrence, Local, Retrospective Studies, Stem Cell Transplantation, T-Lymphocytes, Transplantation, Homologous, Treatment Outcome, Young Adult