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It is unknown whether favorable HLA class II alleles may attenuate HIV-1 through selection pressure in a manner similar to that of protective HLA class I alleles. We investigated the relationship between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. No associations were found between individual alleles and lower replication capacity, suggesting no significant HIV-1 attenuation by HLA class II-restricted Gag-specific CD4(+) T cell immune pressure.

Original publication

DOI

10.1128/JVI.06533-11

Type

Journal article

Journal

J Virol

Publication Date

01/2012

Volume

86

Pages

1273 - 1276

Keywords

Alleles, CD4-Positive T-Lymphocytes, HIV Infections, HIV-1, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Humans, Peptide Hydrolases, Virus Replication, gag Gene Products, Human Immunodeficiency Virus