Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study
Jamil Z., VanBuskirk K., Mweetwa M., Mouksassi S., Smith G., Ahmed T., Chandwe K., Denno DM., Fahim SM., Kelly P., Mahfuz M., Mallawaarachchi I., Marie C., Moore SR., Petri WA., Ali SA., Ahmed K., Ahmed S., Alam MA., Amadi B., Banda R., Dars S., Das S., Denson LA., Hossain MS., Hotwani A., Iqbal J., Iqbal NT., Jakhro S., Kabir F., Kazhila L., Liu TC., Mann BJ., Memon W., Moskaluk CA., Qureshi AK., Ragahavan SS., Rahman M., Rahman N., Sadiq K., Sarker SA., Sullivan PB., Tarr PI., Tearney GJ., Umrani F., Yilmaz OH.
Background: Environmental enteric dysfunction (EED) is a precursor of growth faltering in children living in impoverished conditions who are frequently exposed to environmental toxins and enteropathogens, leading to small bowel inflammatory, malabsorptive, and permeability derangements and low-grade chronic systemic inflammation. Objectives: We explored the association between anthropometrics and duodenal histologic features of EED among children from 3 lower middle-income country centers. Methods: In this cross-sectional study, Pakistani children (n = 63) with wasting, Bangladesh children (n = 116) with stunting or at risk for stunting (height-for-age Z score [HAZ]