Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The central role of HIV-specific cellular immunity in controlling HIV replication is now established. Knowledge of how the virus in the majority of infected persons successfully evades these immune responses is critical to vaccine design. Virus escape from recognition by HIV-specific cytotoxic T-lymphocyte (CTL) responses has been a contentious issue for almost a decade, but recent data from the SIV macaque model of HIV infection suggest that CTL escape is a major factor in AIDS pathogenesis. This review describes the challenges to investigating CTL escape in HIV infection, and discusses the implications of recent studies in macaques and humans to improving our understanding of how effective immune-mediated control of HIV may ultimately be achieved. © 2000 Ashley Publications Ltd.

Original publication

DOI

10.1517/14728222.4.3.297

Type

Journal article

Journal

Expert Opinion on Therapeutic Targets

Publication Date

01/06/2000

Volume

4

Pages

297 - 312