Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Pediatric HIV-1 infection is characterized by rapid disease progression and without antiretroviral therapy (ART), more than 50% of infected children die by the age of 2 years. However, a small subset of infected children progresses slowly to disease in the absence of ART. This study aimed to identify functional characteristics of HIV-1-specific T cell responses that distinguish children with rapid and slow disease progression. Fifteen perinatally HIV-infected children (eight rapid and seven slow progressors) were longitudinally studied to monitor T cell polyfunctionality. HIV-1-specific interferon (IFN)-γ(+) CD8(+) T cell responses gradually increased over time but did not differ between slow and rapid progressors. However, polyfunctional HIV-1-specific CD8(+) T cell responses, as assessed by the expression of four functions (IFN-γ, CD107a, TNF-α, MIP-1β), were higher in slow compared to rapid progressors (p=0.05) early in infection, and was associated with slower subsequent disease progression. These data suggest that the quality of the HIV-specific CD8(+) T cell response is associated with the control of disease in children as has been shown in adult infection.

Original publication

DOI

10.1089/AID.2010.0227

Type

Journal article

Journal

AIDS Res Hum Retroviruses

Publication Date

09/2011

Volume

27

Pages

1005 - 1012

Keywords

CD8-Positive T-Lymphocytes, Chemokine CCL4, Child, Preschool, Disease Progression, HIV Antigens, HIV Infections, HIV-1, Humans, Infant, Infant, Newborn, Interferon-gamma, Lysosomal-Associated Membrane Protein 1, Tumor Necrosis Factor-alpha