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HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope. These data may help explain the observed association between HLA-B*5703 and long-term control of viremia.

Original publication

DOI

10.1128/JVI.00465-07

Type

Journal article

Journal

J Virol

Publication Date

08/2007

Volume

81

Pages

8346 - 8351

Keywords

Amino Acid Sequence, Gene Products, gag, HIV Infections, HIV-1, HLA-B Antigens, Humans, Immunodominant Epitopes, Likelihood Functions, Mutation, Phylogeny, Virus Replication