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To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8+ response that is associated with the control of viremia. These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.

Original publication

DOI

10.1128/JVI.02689-06

Type

Journal article

Journal

J Virol

Publication Date

04/2007

Volume

81

Pages

3667 - 3672

Keywords

Amino Acid Sequence, CD8-Positive T-Lymphocytes, Epitopes, T-Lymphocyte, Gene Products, gag, HIV-1, HLA-B Antigens, HLA-B13 Antigen, Humans, Molecular Sequence Data, Mutation