Prmt5: A guardian of the germline protects future generations
Berrens RV., Reik W.
Primordial germ cells (PGCs) are the embryonic precursors of the germ cell lineage that form sperm and egg cells. It is of great importance to preserve the germline from DNA damage and potentially from epimutations in order to ensure the survival of future generations. Recent research highlights the role of the protein arginine methyltransferase 5 (PRMT5) as an important player in DNA protection during germline development in the mouse (Kim et al, & Li et al,). Protecting the genetic integrity of the germline is of outmost importance. Two novel studies establish multiple roles of PRMT5 in safe-guarding genomic integrity of PGCs, beyond earlier proposed roles in the induction of germline fate.