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<jats:p>Oligonucleotides can bind to mRNA and alter gene expression, but require backbone modifications for clinical use. We show that attaching pyrene or anthraquinone to the ribose sugar next to an artificial triazole backbone restores duplex stability and splice switching ability in cells.</jats:p>

Original publication

DOI

10.1039/d2cb00100d

Type

Journal article

Journal

RSC Chemical Biology

Publisher

Royal Society of Chemistry (RSC)

Publication Date

16/05/2022