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Experimental serogroup B meningococcal vaccines have induced only poor immune responses and have had little protective efficacy in children younger than 1 year of age. We used ELISA with potassium thiocyanate to compare the average avidity of antibody produced by infants with that of children older than 10 years after systemic disease. Infants produced specific antibody of lower average avidity than older children--a finding that correlates with absence of serum bactericidal activity in the serum samples of the same infants.

Original publication

DOI

10.1016/S0140-6736(00)03405-X

Type

Journal article

Journal

Lancet

Publication Date

16/12/2000

Volume

356

Pages

2065 - 2066

Keywords

Age Factors, Antibodies, Bacterial, Antibody Affinity, Blood Bactericidal Activity, Child, Child, Preschool, Coloring Agents, Enzyme-Linked Immunosorbent Assay, Humans, Infant, Meningitis, Meningococcal, Neisseria meningitidis, Polysaccharides, Bacterial, Thiocyanates