Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Although meningococcal disease is rare in industrialized nations, Neisseria meningitidis holds a prominent position amongst pediatric infections because of the dramatic clinical presentation of the disease, high mortality, epidemic potential and the recent disappearance of many other important infectious diseases in developed countries through improvements in public health and vaccination. The precise nature of natural immunity to meningococci remains unknown, although a complex interaction between the organism and nasopharyngeal mucosal barrier, innate immune mechanisms and acquired immunity is involved. Study of the mechanisms of natural immunity may provide the key to development of vaccines that can reduce the burden of disease in early childhood.


Journal article



Publication Date





1327 - 1346


Antibodies, Bacterial, Antibody-Dependent Cell Cytotoxicity, Antigens, Bacterial, Child, Preschool, Complement Activation, Humans, Immunity, Cellular, Immunity, Innate, Immunity, Mucosal, Infant, Meningococcal Infections, Meningococcal Vaccines, Nasopharynx, Neisseria meningitidis, Phagocytosis, Polysaccharides, Bacterial, Serotyping