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Serogroup B Neisseria meningitidis is a frequent cause of invasive meningococcal disease, yet there are no effective vaccines suitable for routine immunisation. Limited efficacy has been shown with meningococcal outer membrane vacccines in children 4 years and older. Here we review the status of current research and consider new approaches to development of meningococcal serogroup B vaccines.

Type

Journal article

Journal

Arch Dis Child

Publication Date

07/2002

Volume

87

Pages

13 - 17

Keywords

Bacterial Outer Membrane Proteins, Child, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Exotoxins, Humans, Lipopolysaccharides, Meningitis, Meningococcal, Meningococcal Vaccines, Neisseria meningitidis