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Acute leukaemia in early childhood - and mainly infant leukaemia (IL) - is characterized by acquired genetic alterations, most commonly by the presence of distinct MLL rearrangements (MLL-r). The aim of this study was to investigate possible correlations between clinical features and molecular analyses of a series of 545 childhood leukaemia (≤24 months of age) cases: 385 acute lymphoblastic leukaemia (ALL) and 160 acute myeloid leukaemia (AML). The location of the genomic breakpoints was determined in a subset of 30 MLL-r cases. The overall survival of the investigated cohort was 60·5%, as determined by the Kaplan-Meier method. Worse outcomes were associated with age at diagnosis ≤6 months (P 

Original publication

DOI

10.1111/bjh.12250

Type

Journal article

Journal

Br J Haematol

Publication Date

04/2013

Volume

161

Pages

224 - 236

Keywords

Brazil, Child, Preschool, Chromosome Breakpoints, Disease-Free Survival, Female, Histone-Lysine N-Methyltransferase, Humans, Infant, Infant, Newborn, Introns, Leukemia, Myeloid, Acute, Male, Myeloid-Lymphoid Leukemia Protein, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Survival Rate