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Since the first World Health Organization notification on 31 December 2019, coronavirus disease 2019 (COVID-19), the respiratory disease caused by the coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has been responsible for over four million confirmed infections and almost 300 000 deaths worldwide. The pandemic has led to over half of the world's population living under lockdown conditions. To allow normal life to resume, public health interventions will be needed to prevent further waves of infections as lockdown measures are lifted. As one of the most effective countermeasures against infectious diseases, an efficacious vaccine is considered crucial to containing the COVID-19 pandemic. Following the publication of the genome sequence of SARS-CoV-2, vaccine development has accelerated at an unprecedented pace across the world. Here we review the different platforms employed to develop vaccines, the standard timelines of development and how they can be condensed in a pandemic situation. We focus on vaccine development in the UK and vaccines that have entered clinical trials around the world.

Original publication

DOI

10.1111/imm.13222

Type

Journal article

Journal

Immunology

Publication Date

07/2020

Volume

160

Pages

223 - 232

Keywords

coronavirus disease 2019, severe acute respiratory syndrome coronavirus-2, vaccine, Animals, COVID-19, COVID-19 Vaccines, Clinical Trials as Topic, Coronavirus Infections, Humans, Pandemics, Pneumonia, Viral, Protein Subunits, United Kingdom, Vaccines, Attenuated, Vaccines, DNA, Vaccines, Synthetic, Viral Vaccines