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CMV is associated with immunosenescence and reduced vaccine responses in the elderly (>70 yr). However, the impact of CMV in young adults is less clear. In this study, healthy UK and Senegalese adults aged 18-50 yr (average, 29 yr) were vaccinated with the Ebola vaccine candidate chimpanzee adenovirus type 3-vectored Ebola Zaire vaccine (ChAd3-EBO-Z) and boosted with modified vaccinia Ankara Ebola Zaire-vectored (MVA-EBO-Z) vaccine. CMV carriage was associated with an expansion of phenotypically senescent CD4+ and CD8+ T cells expressing CD57 and killer cell lectin-like receptor G1 (KLRG1), which was negatively associated with vaccine responses in both cohorts. Ebola-specific T cell responses induced by vaccination also contained significantly increased frequencies of terminally differentiated CD57+KLRG1+ cells in CMV seropositive (CMV+) individuals. This study suggests that CMV can also affect vaccine responses in younger adults and may have a particularly marked impact in many developing countries where CMV seroprevalence is almost universal.

Original publication

DOI

10.1084/jem.20200004

Type

Journal article

Journal

J Exp Med

Publication Date

06/07/2020

Volume

217

Keywords

Adult, CD4-Positive T-Lymphocytes, CD57 Antigens, CD8-Positive T-Lymphocytes, Cell Differentiation, Cell Proliferation, Cellular Senescence, Cytomegalovirus Infections, Ebola Vaccines, Humans, Immunologic Memory, Lectins, C-Type, Middle Aged, Phenotype, Receptors, Immunologic, Seroepidemiologic Studies, T-Lymphocytes, Young Adult