Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The European Commission has granted Marketing Authorisation to Janssen for a new Ebola vaccine, developed in partnership with the University of Oxford.

The two-dose Ebola vaccine regimen, Zabdeno® (Ad26.ZEBOV) and Mvabea® (MVA-BN-Filo), has been developed by the Janssen Pharmaceutical Companies of Johnson & Johnson for the prevention of Ebola Virus Disease caused by the Zaire Ebola virus species. The vaccine regimen leveraged Janssen’s AdVac® vaccine technology, plus Bavarian Nordic’s established MVA-BN® technology. It is specifically designed to induce long-term immunity against the Ebola virus in adults and children aged one year and above. As such, it can be used to support preventive vaccination in countries most at risk of outbreaks.

The University of Oxford played an important role in supporting the development of this vaccine. In response to the West Africa Ebola crisis, we collaborated in a unique, multi-partner global effort to accelerate the vaccine through multiple clinical trials across three continents.

'In 2014 the team at the Oxford Vaccine Group asked for volunteers to take part in a ‘first in human’ study of a new vaccine schedule against Ebola virus disease, which at that time was causing a devastating outbreak in West Africa,' says Professor Matthew Snape, the Chief Investigator on the Ebola vaccine project. 'The response from the public was overwhelming, and within a few months we knew enough about the vaccine and its safety to allow progression to studies enrolling many thousands of participants in sub-Saharan Africa.

'To see this work result in a vaccine approved for prevention of this devastating illness is wonderful, and a real vindication of what was an extraordinary effort by the study team and participants. The parallels with the current COVID-19 outbreak and vaccine studies are obvious, and both demonstrate the importance of investing in research to maintain a skilled team of research scientists, nurses and doctors able to deliver these challenging studies at great speed.'

The Ebola vaccine has already been deployed in the North Kivu region of the Democratic Republic of the Congo (DRC), following recommendation from the WHO’s Strategic Advisory Group of Experts (SAGE), and in Rwanda –following conditional approval in 2019 under an ‘exceptional emergency’ –as part of outbreak containment efforts in the region. With the world currently focused on stopping the COVID-19 pandemic, the need for safe and effective vaccines to protect vulnerable populations from emerging infectious diseases has never been more apparent. Approval of the vaccine by the European Commission marks a significant moment in the ongoing public health effort with the aim to prevent new Ebola outbreaks before they start.

Similar stories

Oxford Vaccine Group among winners at NHS Parliamentary awards

Researchers behind the Oxford AstraZeneca coronavirus vaccine have been recognised for their excellence at a healthcare awards ceremony.

New book highlights life-saving role vaccines play in prevention of killer diseases

'Brain Fever', a new book by internationally-renowned medical scientist Professor Richard Moxon, describes the decades of research that contribute to the development of vaccines for life-threatening illnesses such as meningitis, and how immunisation has been our greatest public health intervention.

Mixed Oxford/Pfizer vaccine schedules generate robust immune response against COVID-19, finds Oxford-led study

Alternating doses of the Oxford-AstraZeneca and Pfizer-BioNTech vaccines generate robust immune responses against COVID-19, according to researchers running the University of Oxford-led Com-COV study.

Delayed second dose and third doses of the Oxford-AstraZeneca vaccine lead to heightened immune response

Research on the ChAdOx1 nCoV-19, also known as the Oxford-AstraZeneca vaccine, indicates that a long interval between first and second doses does not compromise the immune response after a late second dose.

First trial participants vaccinated with Oxford COVID-19 variant vaccine

The University of Oxford in partnership with AstraZeneca began vaccinations on 27 June 2021 for a new phase in human trials to test a COVID-19 vaccine ‘AZD2816’ in volunteers against the B.1.351 variant of concern – commonly known as the Beta variant.

Oxford researchers identify levels of antibody protection required to prevent symptomatic COVID-19

Researchers from the University of Oxford have today released their findings about the so-called ‘correlates of protection’ against symptomatic COVID-19; potentially a tool to speed up safe development of new vaccines which may assist regulators in assessing the likely potency of any new COVID-19 vaccine without the need for Phase III efficacy trial data.