I am a CRUK Clinical Research Fellow, working towards a DPhil in Cancer Science, supervised by Andi Roy and Tom Milne. As an undergraduate I studied Chemistry, then Graduate Entry Medicine at the University of Oxford. After qualifying I undertook clinical medical training as a Paediatric NIHR Academic Clinical Fellow and then Haematology Specialty Registrar in London.
My DPhil aims to understand how developmentally regulated characteristics of lymphoid progenitors provide the molecular context for initiation and evolution of infant ALL. Systematic comparison of normal lymphopoiesis and infant ALL leukaemia using gene expression and epigenetic profiles, will determine developmental stage specific genes/pathways which are permissive for leukaemic transformation in MLLr infant ALL. Ultimately, these results will help identify targeted therapies for molecular pathways relevant to infant ALL.
Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies.
Khan AO. et al, (2022), Cancer Discov
Primary post-transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 paediatric patients.
Taj MM. et al, (2021), Br J Haematol
The Origin of B-cells: Human Fetal B Cell Development and Implications for the Pathogenesis of Childhood Acute Lymphoblastic Leukemia.
Jackson TR. et al, (2021), Front Immunol, 12
NUTRITIONAL RISK IN HOSPITALISED CHILDREN: AN ASSESSMENT OF TWO INSTRUMENTS
Ling RE. et al, (2010), JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 50, E182 - E182