IDRM Transition Fellow
Nancy Stathopoulou is an IDRM Transition Fellow at the Department of Paediatrics, University of Oxford.
Nancy holds a degree in Molecular Biology and Genetics from the University of Thrace in Greece, MSc in Biomedical Sciences and a PhD in Developmental Biology from the Medical School of the University of Patras in Greece, with research performed in Greece and the UK (NIMR, now Crick Institute). After completing her PhD, Nancy moved to the UCL Cancer Institute to start her postdoctoral work in the Epigenetic Signalling lab, led by Dr. Steen Ooi, where she gained extensive experience on epigenetics and embryonic stem cells and identified novel factors regulating DNA methylation. In 2016 she joined the Cardiovascular Morphogenesis group, led by Prof. Pete Scambler at the UCL Great Ormond Street Institute of Child Health (GOS ICH), where she combined her knowledge on developmental biology and epigenetics to study cardiovascular development.
Nancy joined the Institute of Developmental and Regenerative Medicine (IDRM) in June 2023 to set up her team within the cardiology theme. The focus of her research is on the genetics and epigenetics of congenital heart disease. The aim of her group is to explore the basic biological mechanisms that control normal cardiovascular development and understand how genetic and epigenetic factors can lead to congenital heart disease, with the long-term vision to enable the development of new therapeutic approaches.
Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice.
Maniou E. et al, (2023), Development (Cambridge, England), 150
CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression.
Stathopoulou A. et al, (2023), Cardiovascular research, 119, 2089 - 2105
CaudalFgfr1disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice
Maniou E. et al, (2023)
Setd5 is required in cardiopharyngeal mesoderm for heart development and its haploinsufficiency is associated with outflow tract defects in mouse.
Cheung MY-Q. et al, (2021), Genesis, 59
A novel requirement for DROSHA in maintenance of mammalian CG methylation.
Stathopoulou A. et al, (2017), Nucleic Acids Res, 45