Research groups
Manman Guo
Postdoctoral Researcher
My work centres on pre-clinical studies related to bacterial vaccine development. Specifically, I am engaged in developing immunoassays to assess immune parameters for establishing a new controlled human challenge model against Clostridium difficile. Additionally, I am involved in studying immune responses to evaluate protection against paratyphoid infection by a combination vaccine.
My passion lies in translational medicine research, a field I have been involved in since 2015, when I worked as a postdoctoral researcher at NDORMS, University of Oxford. During this period, I immersed myself in investigating immune regulations associated with drug development in multiple myeloma, as well as conducting target validation studies of endometriosis.
Prior to that, I obtained my PhD from the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee. During my doctoral studies, I focused on the phagocytosis of macrophages upon activation, employing a range of methodologies including biochemistry, cell biology, and proteomic approaches.
Recent publications
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Connecting single-nucleotide polymorphisms, glycosylation status, and interactions of plasma serine protease inhibitors.
Wu D. et al, (2023), Chem, 9, 665 - 681
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Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma.
Kurata K. et al, (2023), Blood Cancer J, 13
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Cereblon pathway biomarkers and immune profiles in patients with myeloma receiving post-ASCT lenalidomide maintenance (LEOPARD).
Kalff A. et al, (2021), Leuk Lymphoma, 62, 2981 - 2991
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VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System.
Cianfanelli FR. et al, (2016), PLoS pathogens, 12
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High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow derived macrophages.
Guo M. et al, (2015), Proteomics, 15, 3169 - 3174