Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

Contact information


joe.harman@ndcls.ox.ac.uk

Websites

Joe Harman

MRes, BSc (Hons)

DPhil student

I am a Medical Sciences DPhil student primarily co-supervised by Thomas Milne and Marella de Bruijn. I am additionally co-supervised by Irene Roberts and Edward Morrissey. I finished my BSc Biomedical Science 2013 and MRes Medical Research in 2015 at the University of Reading. I then worked as a research assistant in the de Bruijn lab, before starting my DPhil program.

My research interests focus on the creation and usage of gene regulatory networks to explain biological processes. I have used bioinformatics based approaches to establish transcription factor interaction networks that describe the transcriptional landscape downstream of the MLL-AF4 fusion protein in MLL-rearranged leukaemia. In parallel I have also explored the networks that control the embryonic generation of haematopoietic stem cells through an endothelial-to-haematopoietic transition. A key factor in both of these network models is the RUNX1 transcription factor, which is overexpressed by MLL-AF4 and is critically required for the endothelial-to-haematopoietic transition.