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Angela Minassian
MA (Cantab), MRCP, DPhil, FRCPath
Associate Professor
- Chief Investigator Malaria Vaccine Clinical Trials
- Research Fellow Wolfson College
- Honorary Consultant in Infectious Diseases (Oxford University Hospitals NHS Foundation Trust)
- Vice-Chair Graduate Studies Committee (Medical Sciences Division)
I am an infectious diseases physician by training and lead a clinical malaria vaccine programme at the University of Oxford. This involves testing first-time-in-human vaccines against Plasmodium falciparum and Plasmodium vivax, incorporating controlled human malaria infection to test vaccine efficacy.
I am passionate about building relationships and transferring skills to empower the research teams where malaria is endemic, and our trials now span Phase 1/2 in the UK and across East and West Africa. I also currently co-lead the EDCTP3-funded 2nd-Generation Malaria Vaccine Consortium (MVC-2G).
Using the platform of the malaria human challenge model I also conduct experimental medicine research to explore mechanisms of disease tolerance, and am developing a novel model of relapse for Plasmodium vivax. I have also run clinical trials of vaccines against emerging pathogens and have an interest in developing new human challenge models of infection with which to assess new vaccines.
Recent publications
SARS-CoV-2-Specific Immune Responses to Vaccination in Children and Adolescents with Suppressed Immune Systems: A Prospective, Observational Study.
Journal article
Brugha R. et al, (2026), J Pediatr, 289
B and T cell responses to pre-erythrocytic R21/Matrix-M and blood-stage RH5.1/Matrix-M malaria vaccines in endemic settings.
Journal article
Bundi CK. et al, (2026), Front Immunol, 17
Reactogenicity and immunogenicity following heterologous and homologous third dose COVID-19 vaccination in UK adolescents (Com-COV3): A randomised controlled non-inferiority trial.
Journal article
Kelly E. et al, (2026), J Infect, 92
Structural basis for synergistic antibody protection against the essential malaria invasion complex protein RIPR
Preprint
Williams BG. et al, (2025)
Synergistic non-neutralizing plasma antibodies to PfRH5 drive potent malaria parasite growth inhibition
Preprint
Marchioni J. et al, (2025)