Research groups
Alyssa Hill
PhD
Group Leader - Oligo Biology Drug Development
Biography
Alyssa Hill completed a Ph.D. in Microbiology in 2017. Her doctoral work focused on the biophysical properties of RNA and was supported by a Graduate Research Fellowship from the U.S. National Science Foundation (NSF). From 2017 to 2023, Alyssa carried out postdoctoral work at Eidgenössische Technische Hochschule (ETH) Zürich in Switzerland. Her projects tackled delivery challenges for nucleic acid therapeutics, particularly small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs), and ASO conjugates, with the support of the Novartis Research Foundation (FreeNovation Grant), the Swiss National Science Foundation (Spark Grant), and the Roche Innovation Center Copenhagen. Alyssa is a former McNair Scholar committed to achieving higher diversity, equity, and inclusion (DEI) in STEM, with prior awards from DEI initiatives such as Fix The Leaky Pipeline (ETH domain). Alyssa currently is Group Leader - Oligo Biology Drug Development. She leads in vitro screening and in vivo pharmacokinetics/pharmacodynamics work streams within the TransNAT and CureHeart consortia.
Recent publications
Model selection in preclinical nucleic acid therapeutics research.
Journal article
Oliver PL. and Hill AC., (2026), Commun Biol, 9
Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages.
Journal article
Dhara D. et al, (2025), Nucleic Acids Res, 53
Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA-Charge Neutral Linkages for Enhanced Splice-Switching Antisense Oligonucleotides.
Journal article
Kennett A. et al, (2025), Angew Chem Int Ed Engl, 64
Accurately modelling RNase H-mediated antisense oligonucleotide efficacy
Preprint
Hill B. et al, (2025)
Synthesis, Biophysical and Biological Evaluation of Splice-Switching Oligonucleotides with Multiple LNA-Phosphothiotriester Backbones.
Journal article
Dhara D. et al, (2024), J Am Chem Soc, 146, 29773 - 29781