Contact information
fatima.dhalla@paediatrics.ox.ac.uk
fatima.dhalla@idrm.ox.ac.uk
Fatima Dhalla
Postdoctoral Researcher
Dr Fatima Dhalla is a consultant clinical immunologist and senior postdoctoral scientist in Developmental Immunology Group in the Institute of Developmental and Regenerative Medicine. Her clinical work focuses on patients with inborn errors of immunity and diagnostic laboratory immunology, and fuels research projects that set out to define the genetic causes, develop diagnostic tests and establish best treatment practices and for patients with rare and undefined inborn errors of immunity. Her primary research focus lies in thymic stromal cell biology from fundamental aspects of their development, function and maintenance to more translational studies including models of human congenital thymic defects, thymic involution, and strategies to rejuvenate or boost the function of the thymus. She also has significant teaching responsibilities, including for the MSc in Integrated Immunology and PGCert/Dip/MSc in Paediatric Infectious Diseases.
Key publications
Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells.
Journal article
Klein F. et al, (2023), Nat Commun, 14
Inborn errors of thymic stromal cell development and function.
Journal article
Kreins AY. et al, (2021), Semin Immunopathol, 43, 85 - 100
FOXN1 deficient nude severe combined immunodeficiency.
Journal article
Rota IA. and Dhalla F., (2017), Orphanet J Rare Dis, 12
Recent publications
FOXN1 remodels chromatin access and schedules fitness during thymus ontogeny
Preprint
Dhalla F. et al, (2026)
Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency.
Journal article
Blanco E. et al, (2025), J Exp Med, 222
European Society for Immunodeficiencies guidelines for the management of patients with congenital athymia.
Journal article
Kreins AY. et al, (2024), J Allergy Clin Immunol, 154, 1391 - 1408
Normalization of C1 Inhibitor in a Patient with Hereditary Angioedema.
Journal article
Peters NE. et al, (2024), N Engl J Med, 391, 56 - 59
Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases.
Journal article
Pagnamenta AT. et al, (2023), Genome Med, 15
Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells.
Journal article
Klein F. et al, (2023), Nat Commun, 14
Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK.
Journal article
Shields AM. et al, (2022), Clin Exp Immunol, 209, 247 - 258
Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment.
Journal article
Handel AE. et al, (2022), Sci Adv, 8
Resolving the polygenic aetiology of a late onset combined immune deficiency caused by NFKB1 haploinsufficiency and modified by PIK3R1 and TNFRSF13B variants.
Journal article
Hargreaves CE. et al, (2022), Clin Immunol, 234