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In a Medium interview, Professor Matthew Wood, a professor of Neuroscience in the Department of Paediatrics, talks about his work and the advances that a new Rare Diseases Centre could herald for the future of rare disease and genetics.
New MenB Vaccine Shows Promise in Early-Stage Trial Results
19 May 2025
The outcome of a trial published in Science Translational Medicine, shows encouraging results for a new vaccine targeting group B meningococcus (MenB), a significant cause of meningococcal disease worldwide, and establishes proof-of-concept in humans that a gene-based vaccine platform can induce protective antibody responses against bacteria.
Study identifies key immune structures in the gut that may drive coeliac disease
6 May 2025
Researchers in Oxford have found structures of immune cells in the gut that may be driving the response to gluten in people with coeliac disease and could provide a target for future therapies.
New study shows that early support for children living in marginalised communities can improve their developmental outcomes
29 January 2025
Research by experts at the Department of Paediatrics, and published in the European Journal of Paediatrics shows that early interventions of support to the development of children living in disadvantaged settings, can significantly improve their neurodevelopmental outcomes during early childhood.
Trial results for first vaccine against blood-stage malaria show it is well-tolerated and offers effective protection
10 December 2024
Results of a clinical trial into a new malaria vaccine candidate (RH5.1/Matrix-M) show it is well-tolerated and offers effective protection against the blood-stage of the disease – the first inoculation to do so.
Typhoid vaccine trial confirms sustained protection for older children
10 October 2024
A single dose of typhoid conjugate vaccine (TCV) offers safe, effective protection against typhoid two years after vaccination in all children, and sustained protection for older children at three to five years post immunisation, according to a report by researchers at the Oxford Vaccine Group and icddr,b. But it also shows a decline in protection at the later timepoints among children vaccinated at younger ages.
New research identifies autoimmunity against a key anti-inflammatory regulator in inflammatory bowel disease
- Clinical Trials
- Department
- Gastroenterology
- Immunology
- Publication
- Research
- Research Methods
- University
4 August 2024
A ground-breaking study, published by the New England Journal of Medicine, has identified a new disease-inducing mechanism for inflammatory bowel disease (IBD) in which the immune system attacks its own regulatory function.
New discovery renews hope for thousands with neurodevelopment disorders
12 July 2024
A global collaboration led by scientists at the University of Oxford has discovered that genetic variants in a specific gene cause a rare neurodevelopmental disorder (NDD). NDD is a collective term for severe impairments in how the brain functions that impact learning, behaviour, speech, and movement. Most NDDs are thought to be genetic and caused by changes to DNA, however, to date, around 60% of individuals with these conditions do not know the specific DNA change that causes their disorder.
Research shows early life immunity increases HIV cure/remission in male infants
10 June 2024
New research published by scientists at the University of Oxford, the University of KwaZulu-Natal and the Africa Health Research Institute in South Africa, and the Ragon Institute of Mass General, MIT and Harvard, USA, shows that male infants are more likely to achieve HIV cure/remission than females.
New research assesses the function of a major genetic cause of neurodevelopmental disorders
22 May 2024
New research, published today, has defined the functional impacts of hundreds of variants in a gene that is a major cause of neurodevelopmental disorders.
Ground-breaking study reveals how COVID-19 vaccines prevent severe disease
3 May 2024
A landmark study by scientists at the University of Oxford, has unveiled crucial insights into the way that COVID-19 vaccines mitigate severe illness in those who have been vaccinated.
New protein discovery sheds light on complexity of genetic regulation
21 February 2024
Scientists at the Department of Paediatrics have discovered a new pathway that the human body uses to silence transposable elements or ‘jumping genes’. Dr. Rebecca Berrens, Principal Investigator in the Transposon Group, has published research into the piRNA pathway, a key process our body uses to keep these transposable elements in check.
New model for infant leukaemia announced
25 November 2021
The breakthrough could lead to development of new treatments for infant Acute Lymphoblastic Leukaemia.
Changes in blood cell production over the human lifetime may hold clues to patterns of disease
16 September 2021
A new paper published this week in Cell Reports reveals that changes in the gene expression of blood stem cells occur across the human lifetime; an important step in the understanding and treatment of blood disorders.
Promising discovery for treatment of neuromuscular diseases
23 August 2021
Research led by Carlo Rinaldi and Catheryn Lim discovered that a naturally-occurring isoform of an androgen receptor can be used in therapy for spinal and bulbar muscular atrophy, and shows potential for other diseases.
New book highlights life-saving role vaccines play in prevention of killer diseases
8 July 2021
'Brain Fever', a new book by internationally-renowned medical scientist Professor Richard Moxon, describes the decades of research that contribute to the development of vaccines for life-threatening illnesses such as meningitis, and how immunisation has been our greatest public health intervention.
Latest data on immune response to COVID-19 reinforces need for vaccination, says Oxford-led study
21 June 2021
A new study led by the University of Oxford has found that previous infection, whether symptomatic or asymptomatic, does not necessarily protect you long-term from COVID-19, particularly against new Variants of Concern.
Children’s pain ‘swept under the carpet for too long’ – Lancet Commission
22 October 2020
The launch of Lancet Child and Adolescent Health Commission - the first ever to address paediatric pain - aims to raise the profile of children’s pain from early years to early adulthood.
Featured publication: Advances in oligonucleotide drug delivery
12 August 2020
Oligonucleotides - short DNA or RNA molecules - have great therapeutic application for a range of diseases. Yet, their potential has not been fully unleashed because of challenges linked to efficient delivery. Read more to find out about recent developments in oligonucleotide modifications, and the platforms that may be used to deliver them to target sites.
New design of ‘bike helmet’ style brain scanner used with children for first time
7 November 2019
A new wearable ‘bike helmet’ style brain scanner, that allows natural movement during scanning, has been used in a study with young children for the first time. This marks an important step towards improving our understanding of brain development in childhood.
A call for blood and iron
1 October 2019
Dr Sarah Atkinson’s research team investigates whether an iron export mutation in African populations can protect from anaemia, malaria and bacterial infections.