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Mucosal Immunology
The gastrointestinal immune system has evolved to avoid and counteract the invasion of pathogens. To allow a strong inflammatory immune response during infection but avoid tissue damage there is a need for barrier function and effective immune regulation. Defects in immune regulation lead to immunopathology such as inflammatory bowel disease or celiac disease. We study mechanisms of intestinal barrier function as well as immune regulation by analysing patients with Mendelian disorders that develop intestinal inflammation.
Childhood Leukaemia Research Group
Founded in 2015, we are investigating the link between human fetal haematopoiesis and the origin and biology of childhood leukaemia. In particular, we are interested in the pathogenesis of infant leukaemia, which is a refractory disease that invariably originates in utero.
Fetal and Neonatal Haematology Group
We aim to discover the developmentally-regulated, molecular and biological properties of fetal haematopoietic stem and progenitor cells (HSPC) that provide the permissive cellular context for leukaemia and anemia in early childhood and to investigate the mechanisms which drive these changes.
Paediatric Neuroimaging
Our research focuses on human neonatal brain development. We undertake mechanistic research, clinical trials, methodology development (MRI, EEG and analytical approaches), with a particular focus on infant pain.