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Orbitocerebral aspergillosis has a very high fatality rate and cure is unusual. We describe the successful management of a child with cereberal aspergillosis who had a dramatic response to therapy with a combination of liposomal amphotericin and voriconazole with adjunctive cytokine therapy during immunosuppresive chemotherapy for acute lymphoblastic leukaemia.


Journal article


J Pediatr Hematol Oncol

Publication Date





304 - 307


Amphotericin B, Antifungal Agents, Blindness, Brain Diseases, Child, Preschool, Cytokines, Drug Therapy, Combination, Female, Humans, Neuroaspergillosis, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Pyrimidines, Remission Induction, Tomography, X-Ray Computed, Treatment Outcome, Triazoles, Voriconazole