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PepGen, a therapeutics company targeting severe neuromuscular diseases, including Duchenne muscular dystrophy (DMD), has closed a $45 million Series A funding round led by RA Capital Management with participation from Oxford Sciences Innovation (OSI), the company’s original seed investor.
Coronavirus vaccination linked to substantial reduction in hospitalisation, real-world data suggests
COVID-19 Research Vaccinology
24 February 2021
The first study to describe the effects in real-world communities of the Oxford coronavirus vaccine has been reported in a pre-print publication today, showing a clear reduction in the risk of hospitalisation from COVID-19 amongst those who have received the vaccine.
Oxford vaccine effective against major B.1.1.7 ‘Kent’ coronavirus strain circulating in the UK
COVID-19 Research Vaccinology
5 February 2021
A preprint of ongoing work to assess effectiveness of Oxford’s ChAdOx1 coronavirus vaccine shows that the existing vaccine has similar efficacy against the B.1.1.7 ‘Kent’ coronavirus strain currently circulating in the UK to previously circulating variants.
Children’s pain ‘swept under the carpet for too long’ – Lancet Commission
Neuroimaging Publication Research
22 October 2020
The launch of Lancet Child and Adolescent Health Commission - the first ever to address paediatric pain - aims to raise the profile of children’s pain from early years to early adulthood.
Oxford COVID-19 vaccine begins human trial stage
COVID-19 Recruitment Research Vaccinology
24 April 2020
University of Oxford researchers have begun testing a COVID-19 vaccine in human volunteers in Oxford today. Around 1,110 people will take part in the trial, half receiving the vaccine and the other half (the control group) receiving a widely available meningitis vaccine.
Funding for new COVID-19 studies awarded to OVG's project on infectious disease immunity in children
Awards & Appointments COVID-19 Research Vaccinology
17 April 2020
Five projects from across Oxford University's Medical Sciences Division, including a project led by Professor Matthew Snape from the Oxford Vaccine Group, are among twenty-one new studies into the novel coronavirus which have been funded by the UK government.
Visualising COVID-19 outbreak
COVID-19 Neuroimaging Research Research Methods
2 April 2020
Paediatric Neuroimaging researcher provides real-time case information on epidemiological data from the COVID-19 outbreak.
Oxford COVID-19 vaccine programme opens for clinical trial recruitment
COVID-19 Research Vaccinology
27 March 2020
University of Oxford researchers working in an unprecedented vaccine development effort to prevent COVID-19 have started screening healthy volunteers (aged 18-55) today for their upcoming ChAdOx1 nCoV-19 vaccine trial in the Thames Valley Region. The vaccine based on an adenovirus vaccine vector and the SARS-CoV-2 spike protein is already in production but won’t be ready for some weeks still.
COVID-19 vaccine development
COVID-19 Research Vaccinology
18 March 2020
A vaccine candidate for COVID-19 has been identified by researchers from the Oxford Vaccine Group and Oxford's Jenner Institute.
Typhoid vaccine over 81% effective in tackling disease in Nepal
Research Vaccinology
5 December 2019
A large field study of typhoid conjugate vaccine (TCV) in Nepal has shown a single dose to be safe and effective in reducing typhoid in children aged 9 months to <16 years in an endemic setting.
A call for blood and iron
Publication Research
1 October 2019
Dr Sarah Atkinson’s research team investigates whether an iron export mutation in African populations can protect from anaemia, malaria and bacterial infections.
First steps towards treating myotonic dystrophy type 1
Publication Research
11 September 2019
Collaborative research between teams from the Department of Paediatrics and the Institut de Myologie shows how antisense oligonucleotides can penetrate muscles to treat myotonic dystrophy type 1, a rare muscle disease.
The key to better childhood vaccines might be in our DNA
Publication Research Vaccinology
24 June 2019
PBS features Daniel O'Connor's research on how children's genetic profiles affect their immunity.
Oxford-Harrington Rare Disease Centre to research rare diseases therapies
Research University
28 February 2019
The University of Oxford and Harrington Discovery Institute at University Hospitals have announced a new affiliation to advance therapies for rare diseases. The joint program combines capabilities to improve treatment options globally for patients with rare diseases.
A new frontier in the fight against rare diseases
Research
28 February 2019
In a Medium interview, Professor Matthew Wood, a professor of Neuroscience in the Department of Paediatrics, talks about his work and the advances that a new Rare Diseases Centre could herald for the future of rare disease and genetics.
The power of touch
Neuroimaging Publication Research
18 December 2018
Work published in Current Biology shows that lightly brushing in an infant can reduce pain-related brain activity evoked by a clinically necessary medical procedure.
Is morphine an effective and safe analgesic for premature babies?
Clinical Trials Neuroimaging Research
7 December 2018
The Lancet has published the results of the Procedural Pain in Premature Infants (Poppi) study, ran by the Paediatric Neuroimaging Group and co-ordinated by the National Perinatal Epidemiology Unit (Clinical Trials Unit).
Prestigious fellowship awarded to Paediatrics scholar
Awards & Appointments Neuroimaging Research
28 November 2018
Dr Caroline Hartley, a Senior Postdoctoral Research Fellow in the Paediatric Neuroimaging Group, has been awarded the highly competitive Sir Henry Dale Fellowship.
Bliss to fund the study of pain relief in newborns
Awards & Appointments Neuroimaging Research
9 November 2018
The Paediatric Neuroimaging research team from the Department of Paediatrics at the University of Oxford will receive a £145,987 grant from Bliss, over three years, to fund a project which seeks to improve the measurement and treatment of pain in premature babies.
Halting the spread of salmonella
Research Vaccinology
12 October 2018
There are between 11 and 27 million estimated cases of enteric fever worldwide every year, and 75,000–220,000 deaths. Could vaccination stop the spread of these diesases in the environment?
Pregnant women invited to take part in pioneering diabetes prevention research
Clinical Trials Parents & Carers Recruitment Research
16 July 2018
Dr Matthew Snape leads a study investigating if giving small amounts of oral insulin to babies can prevent type 1 diabetes, thus allowing mothers to protect their children from injecting insulin.