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The majority of Men C conjugate vaccines given in the UK use CRM(197), a mutant diphtheria toxoid, as their protein carrier. We studied the effects of prior immunisation with Men C-CRM(197) conjugate vaccine on immunity to diphtheria in 193 children before and after a booster dose of Men C at 4 years. Baseline diphtheria antibodies were higher in children given four previous doses of Men C (P<0.0001) and tended to be higher following boosting in those who had received three or four doses. This enhanced immunity was not associated with increased reactogenicity.


Journal article



Publication Date





2573 - 2579


Child, Preschool, Diphtheria, Diphtheria Toxoid, Follow-Up Studies, Humans, Immunization Schedule, Infant, Meningococcal Infections, Meningococcal Vaccines, Reproducibility of Results, Time Factors, Vaccines, Conjugate