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We report a 3-year-old boy with anti-N-methyl-D-aspartate receptor encephalitis with a typical syndrome of movement disorder and encephalopathy and evidence of herpes simplex virus (HSV) type 1 infection on brain biopsy. HSV type 1 infection and anti-N-methyl-D-aspartate receptor encephalitis are temporally linked in some cases: this case suggests that prodromal HSV type-1 infection may be clinically subtle and easily missed.

Original publication

DOI

10.1097/INF.0000000000001011

Type

Journal article

Journal

Pediatr Infect Dis J

Publication Date

03/2016

Volume

35

Pages

347 - 349

Keywords

Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Antiviral Agents, Autoantibodies, Biopsy, Brain, Child, Preschool, Encephalitis, Herpes Simplex, Herpesvirus 1, Human, Humans, Immunosuppressive Agents, Magnetic Resonance Imaging, Male, Polymerase Chain Reaction, Treatment Outcome