Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Expression microarray analysis identified CITED1 among a group of genes specifically upregulated in the pubertal mouse mammary gland. At puberty, CITED1 localizes to the luminal epithelial cell population of the mammary ducts and the body cells of the terminal end buds. Generation of CITED1 gene knockout mice showed that homozygous null mutants exhibit retarded mammary ductal growth at puberty and, in addition, dilated ductal structures with a lack of spatial restriction of the subtending branches. Analysis of CITED1 homozygous null and heterozygous null mammary gland gene expression using microarrays suggested that the mammary-specific phenotype seen in the homozygous null females is due to a disturbance in the transcription of a number of key mediators of pubertal ductal morphogenesis. These include estrogen and TGFbeta responsive genes, such as the EGFR/ErbB2 ligand, amphiregulin, whose transcription we suggest is directly or indirectly regulated by CITED1.

Original publication

DOI

10.1038/sj.onc.1209183

Type

Journal article

Journal

Oncogene

Publication Date

09/03/2006

Volume

25

Pages

1532 - 1542

Keywords

Animals, Apoptosis Regulatory Proteins, Female, Gene Expression Profiling, Homozygote, Mammary Glands, Animal, Mice, Mice, Inbred C57BL, Mice, Knockout, Microarray Analysis, Morphogenesis, Nuclear Proteins, Sexual Maturation, Trans-Activators